Wnt Signaling in the Breast: From Development to Disease

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2022 Jun 6

PMID 35663403

Authors

Willy Antoni Abreu de Oliveira

Youssef El Laithy

Alejandra Bruna

Daniela Annibali

Frederic Lluis

Affiliations

Soon will be listed here.

Abstract

The Wnt cascade is a primordial developmental signaling pathway that plays a myriad of essential functions throughout development and adult homeostasis in virtually all animal species. Aberrant Wnt activity is implicated in embryonic and tissue morphogenesis defects, and several diseases, most notably cancer. The role of Wnt signaling in mammary gland development and breast cancer initiation, maintenance, and progression is far from being completely understood and is rather shrouded in controversy. In this review, we dissect the fundamental role of Wnt signaling in mammary gland development and adult homeostasis and explore how defects in its tightly regulated and intricated molecular network are interlinked with cancer, with a focus on the breast.

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