The Association of Vitamin K2 Level with the Glycaemic Status in Type 2 Diabetic Patients: A Case-Control Study

Overview

Journal Indian J Endocrinol Metab

Specialty Endocrinology

Date 2022 Jun 6

PMID 35662764

Authors

Mona Yousry Helmy

Nehal Hamdy Elsaid

Marwa Mohammed Abdel Gwad

Affiliations

Soon will be listed here.

Abstract

Objectives: The target of this work was to investigate vitamin K2 level link to glycaemic status in type 2 diabetes mellitus (T2DM) patients.

Methodology: Sixty T2DM patients were divided into 30 uncontrolled T2DM (group I), 30 controlled T2DM (group II) patients and 30 non-diabetic subjects as the control group. Vitamin K2 level, fasting insulin, homeostasis model assessment insulin resistance (HOMA-IR), fasting blood glucose (FBG), 2-h postprandial blood glucose (PPG), glycosylated haemoglobin (HbA1c) and fasting lipids were documented. Waist circumference (WC) was measured and body mass index (BMI) was calculated.

Results: A highly significant difference between groups was observed in vitamin K2 level ( < 0.001) being 1.61 ± 0.56 ng/ml, 2.04 ± 0.59 ng/ml and 2.96 ± 0.82 ng/ml for groups I, II and III, respectively. Among diabetics, a negative correlation was reported between serum vitamin K2 and FBG ( -0.428), 2-h PPBG ( -0.319), HbA1c ( -0.268), fasting insulin ( -0.49), HOMA-IR ( -0.5), total cholesterol (T-cholesterol) ( -0.335) and LDL-C ( -0.296) with < 0.05. The receiver operating characteristic (ROC) curve emphasized the utility of the discriminated potentiality of serum vitamin K2 as a biomarker for uncontrolled hyperglycaemia in T2DM. The multivariate linear regression has shown that FBG is the only significant independent predictor of serum levels of vitamin K2.

Conclusions: In T2DM patients, serum vitamin K2 level was significantly lower, especially with uncontrolled hyperglycaemia. This suggests that vitamin K2 level has an association with the glycaemic status in T2DM.

Citing Articles

Vitamin K2 in Health and Disease: A Clinical Perspective.

Zhang T, OConnor C, Sheridan H, Barlow J Foods. 2024; 13(11).

PMID: 38890875 PMC: 11172246. DOI: 10.3390/foods13111646.

Co-supplementation of Vitamin K2 and Selenium Synergistically Improves Metabolic Status and Reduces Cardiovascular Risk Markers in Dyslipidemic Rabbits.

Atteia H Biol Trace Elem Res. 2023; 201(10):4758-4768.

PMID: 36696048 DOI: 10.1007/s12011-023-03569-4.

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