Predictive Values of Systemic Immune-Inflammation Index in New-Onset Atrial Fibrillation Following Coronary Artery Bypass Grafting

Overview

Journal Braz J Cardiovasc Surg

Specialty Cardiology & Vascular Diseases

Date 2022 Jun 3

PMID 35657307

Authors

Yucel Yilmaz

Saban Kelesoglu

Deniz Elcik

Rifat Ozmen

Nihat Kalay

Affiliations

Soon will be listed here.

Abstract

Introduction: We investigated the relationship between the newly-defined systemic immune-inflammation index and the new-onset atrial fibrillation in patients undergoing coronary artery bypass grafting.

Method: This study included 392 patients who underwent coronary artery bypass grafting. We divided the participants into two groups as those with and without new-onset atrial fibrillation. Prior to coronary artery bypass grafting, we evaluated blood samples, including systemic immune-inflammation index, and other laboratory parameters of the patients. We formulized the systemic immune-inflammation index score as platelet × neutrophil/lymphocyte counts.

Results: The findings revealed that new-onset atrial fibrillation occurred in 80 (20.4%) of 392 patients during follow-ups. Such patients had higher systemic immune-inflammation index, neutrophil/lymphocyte ratio, and C-reactive protein levels than those who did not develop new-onset atrial fibrillation (P<0.001, P<0.001, P=0.010, respectively). In receiver operating characteristic curve analysis, systemic immune-inflammation index levels > 712.8 predicted new-onset atrial fibrillation with a sensitivity of 85% and a specificity of 61.2% (area under the curve: 0.781, 95% confidence interval: 0.727-0.835; P<0.001).

Conclusion: Overall, systemic immune-inflammation index, a novel inflammatory marker, may be used as a decisive marker to predict the development of atrial fibrillation following coronary artery bypass grafting.

Citing Articles

Exploring Inflammatory Markers and Risk Factors Associated with Pericarditis Development after Ablation for Atrial Fibrillation.

Yakut I, Konte H, Ozeke O J Clin Med. 2024; 13(19).

PMID: 39407994 PMC: 11478000. DOI: 10.3390/jcm13195934.

The Significance of Systemic Inflammatory Markers in 'New-Onset Atrial Fibrillation' Following Cardiac Surgeries.

Mittal S, Bhushan R, Jhajhria N, Aiyer P, Grover V Cureus. 2024; 16(5):e59869.

PMID: 38854228 PMC: 11157638. DOI: 10.7759/cureus.59869.

Effects of Preoperative Nutritional Status and Lymphocyte Count on the Development of Early-term Atrial Fibrillation After Coronary Artery Bypass Grafting: A Retrospective Study.

Yilmaz S, Zengin S, Dulger A Braz J Cardiovasc Surg. 2024; 39(3):e20230366.

PMID: 38748866 PMC: 11099827. DOI: 10.21470/1678-9741-2023-0366.

The Role of Pan-Immune-Inflammation Value in Determining the Severity of Coronary Artery Disease in NSTEMI Patients.

Cetinkaya Z, Kelesoglu S, Tuncay A, Yilmaz Y, Karaca Y, Karasu M J Clin Med. 2024; 13(5).

PMID: 38592192 PMC: 10931938. DOI: 10.3390/jcm13051295.

A Prediction Model Based on Systemic Immune-Inflammatory Index Combined with Other Predictors for Major Adverse Cardiovascular Events in Acute Myocardial Infarction Patients.

Li X, Yu C, Liu X, Chen Y, Wang Y, Liang H J Inflamm Res. 2024; 17:1211-1225.

PMID: 38410422 PMC: 10895983. DOI: 10.2147/JIR.S443153.

References

Shao Q, Chen K, Rha S, Lim H, Li G, Liu T . Usefulness of Neutrophil/Lymphocyte Ratio as a Predictor of Atrial Fibrillation: A Meta-analysis. Arch Med Res. 2015; 46(3):199-206. DOI: 10.1016/j.arcmed.2015.03.011. View

Jalife J . Mechanisms of persistent atrial fibrillation. Curr Opin Cardiol. 2013; 29(1):20-7. DOI: 10.1097/HCO.0000000000000027. View

THOMPSON A, Hirsch G, Pearson G . Assessment of new onset postcoronary artery bypass surgery atrial fibrillation: current practice pattern review and the development of treatment guidelines. J Clin Pharm Ther. 2002; 27(1):21-37. DOI: 10.1046/j.1365-2710.2002.00383.x. View

Uysal D, Aksoy F, Ibrisim E . The Validation of the ATRIA and CHA2DS2-Vasc Scores in Predicting Atrial Fibrillation after Coronary Artery Bypass Surgery. Braz J Cardiovasc Surg. 2020; 35(5):619-625. PMC: 7598961. DOI: 10.21470/1678-9741-2019-0274. View

Omae T, Kanmura Y . Management of postoperative atrial fibrillation. J Anesth. 2012; 26(3):429-37. PMC: 3375013. DOI: 10.1007/s00540-012-1330-9. View

Erdogan M, Erdol M, Ozturk S, Durmaz T . Systemic immune-inflammation index is a novel marker to predict functionally significant coronary artery stenosis. Biomark Med. 2020; 14(16):1553-1561. DOI: 10.2217/bmm-2020-0274. View

Kurtul A, Yarlioglues M, Murat S, Ergun G, Duran M, Kasapkara H . Usefulness of the platelet-to-lymphocyte ratio in predicting angiographic reflow after primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction. Am J Cardiol. 2014; 114(3):342-7. DOI: 10.1016/j.amjcard.2014.04.045. View

Ommen S, Gibbons R, Hodge D, Thomson S . Usefulness of the lymphocyte concentration as a prognostic marker in coronary artery disease. Am J Cardiol. 1997; 79(6):812-4. DOI: 10.1016/s0002-9149(96)00878-8. View

Gibson P, Cuthbertson B, Croal B, Rae D, El-Shafei H, Gibson G . Usefulness of neutrophil/lymphocyte ratio as predictor of new-onset atrial fibrillation after coronary artery bypass grafting. Am J Cardiol. 2010; 105(2):186-91. DOI: 10.1016/j.amjcard.2009.09.007. View

10.

Huang J, Zhang Q, Wang R, Ji H, Chen Y, Quan X . Systemic Immune-Inflammatory Index Predicts Clinical Outcomes for Elderly Patients with Acute Myocardial Infarction Receiving Percutaneous Coronary Intervention. Med Sci Monit. 2019; 25:9690-9701. PMC: 6930700. DOI: 10.12659/MSM.919802. View

11.

Ozaydin M, Peker O, Erdogan D, Akcay S, Yucel H, Icli A . Oxidative status, inflammation, and postoperative atrial fibrillation with metoprolol vs carvedilol or carvedilol plus N-acetyl cysteine treatment. Clin Cardiol. 2014; 37(5):300-6. PMC: 6649440. DOI: 10.1002/clc.22249. View

12.

Berkovitch A, Younis A, Grossman Y, Segev S, Kivity S, Sidi Y . Relation of Neutrophil to Lymphocyte Ratio to Risk of Incident Atrial Fibrillation. Am J Cardiol. 2018; 123(3):396-401. DOI: 10.1016/j.amjcard.2018.10.036. View

13.

Hu B, Yang X, Xu Y, Sun Y, Sun C, Guo W . Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014; 20(23):6212-22. DOI: 10.1158/1078-0432.CCR-14-0442. View

14.

Scott Jr L, Li N, Dobrev D . Role of inflammatory signaling in atrial fibrillation. Int J Cardiol. 2018; 287:195-200. PMC: 6447485. DOI: 10.1016/j.ijcard.2018.10.020. View

15.

Ferlinz J . Our unadorned atrial fibrillation: the challenge of new enigmas. Am J Cardiol. 2007; 99(9):1330-3. DOI: 10.1016/j.amjcard.2006.12.046. View

16.

Villareal R, Hariharan R, Liu B, Kar B, Lee V, Elayda M . Postoperative atrial fibrillation and mortality after coronary artery bypass surgery. J Am Coll Cardiol. 2004; 43(5):742-8. DOI: 10.1016/j.jacc.2003.11.023. View

17.

Madjid M, Awan I, Willerson J, Casscells S . Leukocyte count and coronary heart disease: implications for risk assessment. J Am Coll Cardiol. 2004; 44(10):1945-56. DOI: 10.1016/j.jacc.2004.07.056. View

18.

Gasz B, Lenard L, Benko L, Borsiczky B, Szanto Z, Lantos J . Expression of CD97 and adhesion molecules on circulating leukocytes in patients undergoing coronary artery bypass surgery. Eur Surg Res. 2005; 37(5):281-9. DOI: 10.1159/000089237. View

19.

Ducceschi V, DAndrea A, Liccardo B, Alfieri A, Sarubbi B, De Feo M . Perioperative clinical predictors of atrial fibrillation occurrence following coronary artery surgery. Eur J Cardiothorac Surg. 1999; 16(4):435-9. DOI: 10.1016/s1010-7940(99)00217-1. View

20.

Sun Y, Mei Y, Ji Q, Wang X, Feng J, Cai J . [Effect of atorvastatin on postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting]. Zhonghua Yi Xue Za Zhi. 2010; 89(42):2988-91. View