Defective Mitophagy and the Etiopathogenesis of Alzheimer's Disease

Overview

Journal Transl Neurodegener

Publisher Biomed Central

Date 2022 Jun 2

PMID 35655270

Authors

Kuan Zeng

Xuan Yu

Yacoubou Abdoul Razak Mahaman

Jian-Zhi Wang

Rong Liu

Yi Li

Xiaochuan Wang

Affiliations

Soon will be listed here.

Abstract

Accumulation of impaired mitochondria and energy metabolism disorders are non-negligible features of both aging and age-related neurodegeneration, including Alzheimer's disease (AD). A growing number of studies suggest that mitophagy disorders play an important role in AD occurrence and development. The interaction between mitophagy deficits and Aβ or Tau pathology may form a vicious cycle and cause neuronal damage and death. Elucidating the molecular mechanism of mitophagy and its role in AD may provide insights into the etiology and mechanisms of AD. Defective mitophagy is a potential target for AD prevention and treatment.

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