Time Trends for Incidence and Net Survival of Cervical Cancer in Sweden 1960-2014-A Nationwide Population-Based Study

Overview

Journal Cancer Epidemiol Biomarkers Prev

Specialties Biochemistry
Oncology
Public Health

Date 2022 Jun 2

PMID 35654420

Authors

Avalon Sundqvist

Louise Moberg

Paul W Dickman

Thomas Hogberg

Christer Borgfeldt

Affiliations

Soon will be listed here.

Abstract

Background: The aim was to investigate time trends for incidence and long-term net survival in the morphologic subtypes and stages of cervical cancer in Sweden during the period 1960 to 2014.

Methods: Women with invasive cervical cancer were identified through the Swedish Cancer Registry. Incidence and net survival were calculated according to morphology, age at diagnosis, and FIGO stage at diagnosis.

Results: In total, 29,579 cases of invasive cervical cancer between 1960 and 2014 were included. The age-standardized incidence for squamous cell carcinoma (SCC) decreased until 2000; thereafter, the incidence rate stagnated, and a small increase was found in 2014. The incidence of adenocarcinoma continuously increased. The age-standardized 5-year net survival increased. However, decreasing net survival with increasing age was found. A higher stage at diagnosis showed a worse net survival. SCC and adenocarcinoma did not statistically differ as regards net survival in the last years of the study.

Conclusions: Age-standardized 5-year net survival improved between 1960 and 2014. A positive trend for short- and long-term net survival was seen for women ages 18 to 64 years but long-term net survival for women ≥75 years decreased. In this study, age and FIGO stage at diagnosis were found to be important prognostic factors in determining net survival. The morphologies, SCC, and adenocarcinoma did not statistically differ as regards net survival in the last years of the study.

Impact: This study demonstrates longitudinal data on cervical cancer in Sweden for over 50 years with sub analyses on morphology, age, and stage at diagnosis.

Citing Articles

Vulvar cancer incidence and net survival in Sweden 1960 to 2019: A population-based national study.

Moberg L, Sundqvist A, Holmberg E, Dickman P, Borgfeldt C Acta Obstet Gynecol Scand. 2023; 103(3):561-571.

PMID: 38071449 PMC: 10867366. DOI: 10.1111/aogs.14747.

Cervix cytology samples revealed increased methylation of the human markers FAM19A4/miR124-2 up to 8 years before adenocarcinoma.

Lindroth Y, Pedersen L, Alssamaray J, Berglund T, Sundqvist A, Borgfeldt C Acta Obstet Gynecol Scand. 2023; 103(2):378-386.

PMID: 37964497 PMC: 10823397. DOI: 10.1111/aogs.14707.

Overall and Cervical Cancer Survival in Patients With and Without Mental Disorders.

Herweijer E, Wang J, Hu K, Valdimarsdottir U, Adami H, Sparen P JAMA Netw Open. 2023; 6(9):e2336213.

PMID: 37773493 PMC: 10542737. DOI: 10.1001/jamanetworkopen.2023.36213.

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