Research Progress on Mono-ADP-Ribosyltransferases in Human Cell Biology

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2022 Jun 2

PMID 35652091

Authors

Yujie Gan

Huanhuan Sha

Renrui Zou

Miao Xu

Yuan Zhang

Jifeng Feng

Jianzhong Wu

Affiliations

Soon will be listed here.

Abstract

ADP-ribosylation is a well-established post-translational modification that is inherently connected to diverse processes, including DNA repair, transcription, and cell signaling. The crucial roles of mono-ADP-ribosyltransferases (mono-ARTs) in biological processes have been identified in recent years by the comprehensive use of genetic engineering, chemical genetics, and proteomics. This review provides an update on current methodological advances in the study of these modifiers. Furthermore, the review provides details on the function of mono ADP-ribosylation. Several mono-ARTs have been implicated in the development of cancer, and this review discusses the role and therapeutic potential of some mono-ARTs in cancer.

Citing Articles

Privileged Scaffolds for Potent and Specific Inhibitors of Mono-ADP-Ribosylating PARPs.

Nizi M, Sarnari C, Tabarrini O Molecules. 2023; 28(15).

PMID: 37570820 PMC: 10420676. DOI: 10.3390/molecules28155849.

Temporal recruitment of base excision DNA repair factors in living cells in response to different micro-irradiation DNA damage protocols.

Zhao M, Stefanick D, Nadalutti C, Beard W, Wilson S, Horton J DNA Repair (Amst). 2023; 126:103486.

PMID: 37028218 PMC: 10133186. DOI: 10.1016/j.dnarep.2023.103486.

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