Structural Alterations in the Spinal Cord During Progressive Communicating Syringomyelia. An Experimental Study in the Cat

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1987 Jan 1

PMID 3564904

Citations 6

Authors

K Rascher

K H BOOZ

E Donauer

A C NACIMIENTO

Affiliations

Soon will be listed here.

Abstract

A hydrocephalic-hydromyelic condition was induced in adult cats by causing the closure of the lateral apertures with intracisternal injections of kaolin. After displaying the symptoms characteristic of increased intracranial pressure, which lasted about 10-14 days but varied somewhat in intensity from animal to animal, the cats recovered. From approximately the 2nd post-operative week onward, a distended central canal was revealed by ventriculography; subsequently cavities developed in the tissue of the cord that communicated with the canal. Most cavities were located dorsal to the canal. The surfaces of the distended canal and the cavities showed that in ventral areas the ependyma streched but remained intact, whereas in dorsal areas it ruptured, exposing the nerve fibers to the cerebrospinal fluid (CSF). In cats which had been hydrocephalic for up to 2 years the walls of the cavities were covered by gliotic scar tissue; the nerve fibers were no longer exposed directly to the CSF.

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References

Hall P, Godersky J, Muller J, Campbell R, Kalsbeck J . A study of experimental syringomyelia by scanning electron microscopy. Neurosurgery. 1977; 1(1):41-7. DOI: 10.1227/00006123-197707000-00009. View

Leslie R, GWYN D, Morrison C . The fine structure of the ventricular surface of the area postrema of the cat, with particular reference to supraependymal structures. Am J Anat. 1978; 153(2):273-90. DOI: 10.1002/aja.1001530207. View

McLaurin R, Bailey O, Schurr P, INGRAHAM F . Myelomalacia and multiple cavitations of spinal cord secondary to adhesive arachnoiditis; an experimental study. AMA Arch Pathol. 1954; 57(2):138-46. View

Nielsen S, Gauger G . Experimental hydrocephalus: surface alterations of the lateral ventricle. Scanning electron microscopic studies. Lab Invest. 1974; 30(5):618-25. View

Clementi F, Marini D . The surface fine structure of the walls of cerebral ventricles and of choroid plexus in cat. Z Zellforsch Mikrosk Anat. 1972; 123(1):82-95. DOI: 10.1007/BF00337675. View

Hochwald G, Nakamura S, Camins M . The rat in experimental obstructive hydrocephalus. Z Kinderchir. 1981; 34(4):403-10. DOI: 10.1055/s-2008-1063383. View

Becker D, Wilson J, Watson G . The spinal cord central canal: response to experimental hydrocephalus and canal occlusion. J Neurosurg. 1972; 36(4):416-24. DOI: 10.3171/jns.1972.36.4.0416. View

Rascher K, BOOZ K, NACIMIENTO A, Donauer E . The ependyma of the cat central canal, with particular reference to its mitochondria-containing bulbs. Scan Electron Microsc. 1985; (Pt 1):231-8. View

NETSKY M . Syringomyelia; a clinicopathologic study. AMA Arch Neurol Psychiatry. 1953; 70(6):741-77. View

10.

JAMES Jr A, Flor W, Novak G, Strecker E, Burns B . Evaluation of the central canal of the spinal cord in experimentally induced hydrocephalus. J Neurosurg. 1978; 48(6):970-4. DOI: 10.3171/jns.1978.48.6.0970. View

11.

Eisenberg H, McLennan J, Welch K, Treves S . Radioisotope ventriculography in cats with kaolin-induced hydrocephalus. Radiology. 1974; 110(2):399-402. DOI: 10.1148/110.2.399. View

12.

Dohrmann G . Cervical spinal cord in experimental hydrocephalus. J Neurosurg. 1972; 37(5):538-42. DOI: 10.3171/jns.1972.37.5.0538. View

13.

Garfia A, Mestres P, Rascher K . Trinitrophenol lesions of the ventricular wall: a SEM-TEM study. Scan Electron Microsc. 1980; (3):449-56. View

14.

Ogata J, Hochwald G, CRAVIOTO H, Ransohoff J . Light and electron microscopic studies of experimental hydrocephalus. Ependymal and subependymal areas. Acta Neuropathol. 1972; 21(3):213-23. DOI: 10.1007/BF00688500. View

15.

SCHLESINGER E, Antunes J, Michelsen W, Louis K . Hydromyelia: clinical presentation and comparison of modalities of treatment. Neurosurgery. 1981; 9(4):356-65. DOI: 10.1227/00006123-198110000-00002. View

16.

Rascher K, Mestres P . Reaction of the hypothalamic ventricular lining following systemic administration of MSG. Scan Electron Microsc. 1980; (3):457-64. View

17.

Lindberg L, Vasenius L, TALANTI S . The surface fine structure of the ependymal lining of the lateral ventricle in rats with hereditary hydrocephalus. Cell Tissue Res. 1977; 179(1):121-9. DOI: 10.1007/BF00278467. View

18.

Barbera J, Cerda-Nicolas M, Segura D, Broseta J, BARCIA-SALORIO J . Sequential morphological and functional changes in kaolin-induced hydrocephalus. J Neurosurg. 1984; 61(5):918-24. DOI: 10.3171/jns.1984.61.5.0918. View

19.

Eisenberg H, McLennan J, Welch K . Ventricular perfusion in cats with kaolin-induced hydrocephalus. J Neurosurg. 1974; 41(1):20-8. DOI: 10.3171/jns.1974.41.1.0020. View

20.

TORVIK A, Stenwig A . The pathology of experimental obstructive hydrocephalus. Electron microscopic observations. Acta Neuropathol. 1977; 38(1):21-6. DOI: 10.1007/BF00691271. View