DDX3X Structural Analysis: Implications in the Pharmacology and Innate Immunity

Overview

Journal Curr Res Immunol

Specialty Allergy & Immunology

Date 2022 Jun 1

PMID 35647523

Authors

Luigi De Colibus

Melissa Stunnenberg

Teunis B H Geijtenbeek

Affiliations

Soon will be listed here.

Abstract

The human DEAD-Box Helicase 3 X-Linked (DDX3X) is an ATP-dependent RNA helicase involved in virtually every step of RNA metabolism, ranging from transcription regulation in the nucleus to translation initiation and stress granule (SG) formation, and plays crucial roles in innate immunity, as well as tumorigenesis and viral infections. This review discusses latest advances in DDX3X biology and structure-function relationship, including the implications of the recent DDX3X crystal structure in complex with double stranded RNA for RNA metabolism, DDX3X involvement in the cross-talk between innate immune responses and cell stress adaptation, and the roles of DDX3X in controlling cell fate.

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