Therapeutic Effect of Pericytes for Diabetic Wound Healing

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2022 Jun 1

PMID 35647064

Authors

Kyeong Mi Kim

Hyun-Ju An

Sang-Hoon Kim

Juhee Kim

Changgon Sim

Jaemin Lee

Sin Hyung Park

Hyun Il Lee

Inseok Jang

Soonchul Lee

Affiliations

Soon will be listed here.

Abstract

Objective: Numerous attempts have been made to devise treatments for ischemic foot ulcer (IFU), which is one of the most severe and fatal consequences of diabetes mellitus (DM). Pericytes, which are perivascular multipotent cells, are of interest as a treatment option for IFU because they play a critical role in forming and repairing various tissues. In this study, we want to clarify the angiogenic potential of pericytes in DM-induced wounds.

Methods: We evaluated pericyte stimulation capability for tube formation, angiogenesis, and wound healing (cell migration) in human umbilical vein endothelial cells (HUVECs) with and models of high glucose conditions.

Results: When HUVECs were co-cultured with pericytes, their tube-forming capacity and cell migration were enhanced. Our diabetic mouse model showed that pericytes promote wound healing increased vascularization.

Conclusion: The findings of this study indicate that pericytes may enhance wound healing in high glucose conditions, consequently making pericyte transplantation suitable for treating IFUs.

Citing Articles

The cross talk between type II diabetic microenvironment and the regenerative capacities of human adipose tissue-derived pericytes: a promising cell therapy.

Ahmed T, Ahmed S, Elkhenany H, El-Desouky M, Magdeldin S, Osama A Stem Cell Res Ther. 2024; 15(1):36.

PMID: 38331889 PMC: 10854071. DOI: 10.1186/s13287-024-03643-1.

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