Glucocorticoids Improve the Pregnancy Rate and Outcome in Women With Unexplained Positive Autoantibodies: A Systematic Review and Meta-Analysis

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2022 Jun 1

PMID 35646975

Authors

Ting Li

Yilin Yuan

Huixin Liu

Qun Lu

Rong Mu

Affiliations

Soon will be listed here.

Abstract

Systematic Review Registration: [www.ClinicalTrials.gov], identifier [CRD42019124442].

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References

Li C, Zhou J, Huang Z, Pan X, Leung W, Chen L . The Clinical Value and Variation of Antithyroid Antibodies during Pregnancy. Dis Markers. 2020; 2020:8871951. PMC: 7599418. DOI: 10.1155/2020/8871951. View

Malizia B, Hacker M, Penzias A . Cumulative live-birth rates after in vitro fertilization. N Engl J Med. 2009; 360(3):236-43. DOI: 10.1056/NEJMoa0803072. View

Ye S, Gu X, Tao L, Cong J, Wang Y . Efficacy of Different Treatment Regimens for Antiphospholipid Syndrome-related Recurrent Spontaneous Abortion. Chin Med J (Engl). 2017; 130(12):1395-1399. PMC: 5463467. DOI: 10.4103/0366-6999.207471. View

Kilic S, Tasdemir N, Yilmaz N, Yuksel B, Gul A, Batioglu S . The effect of anti-thyroid antibodies on endometrial volume, embryo grade and IVF outcome. Gynecol Endocrinol. 2008; 24(11):649-55. DOI: 10.1080/09513590802531112. View

Shetty S, Ghosh K . Anti-phospholipid antibodies and other immunological causes of recurrent foetal loss--a review of literature of various therapeutic protocols. Am J Reprod Immunol. 2009; 62(1):9-24. DOI: 10.1111/j.1600-0897.2009.00714.x. View

Ubaldi F, Rienzi L, Ferrero S, Anniballo R, Iacobelli M, Cobellis L . Low dose prednisolone administration in routine ICSI patients does not improve pregnancy and implantation rates. Hum Reprod. 2002; 17(6):1544-7. DOI: 10.1093/humrep/17.6.1544. View

Vaquero E, Lazzarin N, Valensise H, Menghini S, Di Pierro G, Cesa F . Pregnancy outcome in recurrent spontaneous abortion associated with antiphospholipid antibodies: a comparative study of intravenous immunoglobulin versus prednisone plus low-dose aspirin. Am J Reprod Immunol. 2001; 45(3):174-9. DOI: 10.1111/j.8755-8920.2001.450309.x. View

Duvan C, Ozmen B, Satiroglu H, Atabekoglu C, Berker B . Does addition of low-dose aspirin and/or steroid as a standard treatment in nonselected intracytoplasmic sperm injection cycles improve in vitro fertilization success? A randomized, prospective, placebo-controlled study. J Assist Reprod Genet. 2006; 23(1):15-21. PMC: 3455434. DOI: 10.1007/s10815-005-9003-3. View

Fawzy M, El-Refaeey A . Does combined prednisolone and low molecular weight heparin have a role in unexplained implantation failure?. Arch Gynecol Obstet. 2013; 289(3):677-80. DOI: 10.1007/s00404-013-3020-8. View

10.

Norgard B, Larsen M, Friedman S, Knudsen T, Fedder J . Decreased chance of a live born child in women with rheumatoid arthritis after assisted reproduction treatment: a nationwide cohort study. Ann Rheum Dis. 2019; 78(3):328-334. DOI: 10.1136/annrheumdis-2018-214619. View

11.

Zhu Q, Wu L, Xu B, Hu M, Tong X, Ji J . A retrospective study on IVF/ICSI outcome in patients with anti-nuclear antibodies: the effects of prednisone plus low-dose aspirin adjuvant treatment. Reprod Biol Endocrinol. 2013; 11:98. PMC: 3852712. DOI: 10.1186/1477-7827-11-98. View

12.

Turi A, Giannubilo S, Zanconi S, Mascetti A, Tranquilli A . Preconception steroid treatment in infertile women with antithyroid autoimmunity undergoing ovarian stimulation and intrauterine insemination: a double-blind, randomized, prospective cohort study. Clin Ther. 2011; 32(14):2415-21. DOI: 10.1016/j.clinthera.2011.01.010. View

13.

Ordi J, Barquinero J, Vilardell M, Jordana R, Tolosa C, Selva A . Fetal loss treatment in patients with antiphospholipid antibodies. Ann Rheum Dis. 1989; 48(10):798-802. PMC: 1003884. DOI: 10.1136/ard.48.10.798. View

14.

Blank M, Shoenfeld Y . Antiphospholipid antibody-mediated reproductive failure in antiphospholipid syndrome. Clin Rev Allergy Immunol. 2009; 38(2-3):141-7. DOI: 10.1007/s12016-009-8146-x. View

15.

Dan S, Wei W, Yichao S, Hongbo C, Shenmin Y, Jiaxiong W . Effect of Prednisolone Administration on Patients with Unexplained Recurrent Miscarriage and in Routine Intracytoplasmic Sperm Injection: A Meta-Analysis. Am J Reprod Immunol. 2015; 74(1):89-97. DOI: 10.1111/aji.12373. View

16.

Moffitt D, Queenan Jr J, Veeck L, Schoolcraft W, Miller C, Muasher S . Low-dose glucocorticoids after in vitro fertilization and embryo transfer have no significant effect on pregnancy rate. Fertil Steril. 1995; 63(3):571-7. DOI: 10.1016/s0015-0282(16)57428-7. View

17.

Ando T, Suganuma N, Furuhashi M, Asada Y, Kondo I, Tomoda Y . Successful glucocorticoid treatment for patients with abnormal autoimmunity on in vitro fertilization and embryo transfer. J Assist Reprod Genet. 1996; 13(10):776-81. DOI: 10.1007/BF02066497. View

18.

Revelli A, Dolfin E, Gennarelli G, Lantieri T, Massobrio M, Holte J . Low-dose acetylsalicylic acid plus prednisolone as an adjuvant treatment in IVF: a prospective, randomized study. Fertil Steril. 2007; 90(5):1685-91. DOI: 10.1016/j.fertnstert.2007.08.037. View

19.

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. PMC: 2707599. DOI: 10.1371/journal.pmed.1000097. View

20.

Litwicka K, Arrivi C, Varricchio M, Mencacci C, Greco E . In women with thyroid autoimmunity, does low-dose prednisolone administration, compared with no adjuvant therapy, improve in vitro fertilization clinical results?. J Obstet Gynaecol Res. 2014; 41(5):722-8. DOI: 10.1111/jog.12615. View