Epigenetics and Neuroinflammation Associated With Neurodevelopmental Disorders: A Microglial Perspective

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2022 Jun 1

PMID 35646933

Authors

Munekazu Komada

Yuhei Nishimura

Affiliations

Soon will be listed here.

Abstract

Neuroinflammation is a cause of neurodevelopmental disorders such as autism spectrum disorders, fetal alcohol syndrome, and cerebral palsy. Converging lines of evidence from basic and clinical sciences suggest that dysregulation of the epigenetic landscape, including DNA methylation and miRNA expression, is associated with neuroinflammation. Genetic and environmental factors can affect the interaction between epigenetics and neuroinflammation, which may cause neurodevelopmental disorders. In this minireview, we focus on neuroinflammation that might be mediated by epigenetic dysregulation in microglia, and compare studies using mammals and zebrafish.

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