Proteomic Alteration of Endometrial Tissues During Secretion in Polycystic Ovary Syndrome May Affect Endometrial Receptivity

Overview

Journal Clin Proteomics

Publisher Biomed Central

Date 2022 Jun 1

PMID 35643455

Authors

Jun Li

Xiaohua Jiang

Caihua Li

Huihui Che

Lin Ling

Zhaolian Wei

Affiliations

Soon will be listed here.

Abstract

Embryo implantation is a complex developmental process that requires coordinated interactions among the embryo, endometrium, and the microenvironment of endometrium factors. Even though the impaired endometrial receptivity of patients with polycystic ovary syndrome (PCOS) is known, understanding of endometrial receptivity is limited. A proteomics study in three patients with PCOS and 3 fertile women was performed to understand the impaired endometrial receptivity in patients with PCOS during luteal phases. Through isobaric tags for relative and absolute quantitation (iTRAQ) analyses, we identified 232 unique proteins involved in the metabolism, inflammation, and cell adhesion molecules. Finally, our results suggested that energy metabolism can affect embryo implantation, whereas inflammation and cell adhesion molecules can affect both endometrial conversion and receptivity. Our results showed that endometrial receptive damage in patients with PCOS is not a single factor. It is caused by many proteins, pathways, systems, and abnormalities, which interact with each other and make endometrial receptive research more difficult.

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