Impact of Various Parameters As Predictors of The Success Rate of Fertilization

Overview

Journal Int J Fertil Steril

Specialty Reproductive Medicine

Date 2022 May 31

PMID 35639653

Authors

Radin Dabbagh Rezaeiyeh

Arian Mehrara

Amin Mohammad Ali Pour

Jafar Fallahi

Sedighe Forouhari

Affiliations

Soon will be listed here.

Abstract

A woman who is infertile is defined as a woman who is unable to conceive after having unprotected sex for more than one year. 20-25% of couples worldwide suffer from infertility each year (60 to 80 million couples). fertilization (IVF) plays a significant role in the treatment of various types of infertility, including fallopian tube defects, endometriosis, immunity, and male causes. IVF is a complex procedure that can be used to aid fertility or prevent genetic problems in the fetus. The objective of this review is to investigate factors that affect IVF failure and success rates. Need for this review is predicated on the different results obtained from previous studies, the high prevalence of infertility, and the lack of a similar study in this field. Articles were regarded as suitable if they evaluated the association between any factor and IVF outcome. A comprehensive search of databases was completed from their inception until March 2021. Our search resulted in 1278 articles. After assessing the titles and abstracts, we selected 70 articles for further reading. Our review shows that the effectiveness of IVF treatment depends on many factors. These include the physical environment, genetics, psychological factors, serum levels of certain hormones, sperm characteristics, as well as the age and body mass index of couples. Based on the results of our study, nutrient supplementation maybe beneficial for the enhancement of semen quality. For better IVF outcome, it is better for obese women to balance their body mass index (BMI) before IVF procedure initiation.

Citing Articles

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The clinical effectiveness of the Mind/Body Program for Infertility on wellbeing and assisted reproduction outcomes: a randomized controlled trial in search for active ingredients.

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References

Sebire N, Foskett M, Fisher R, Rees H, Seckl M, NEWLANDS E . Risk of partial and complete hydatidiform molar pregnancy in relation to maternal age. BJOG. 2002; 109(1):99-102. DOI: 10.1111/j.1471-0528.2002.t01-1-01037.x. View

Liu Y, Wu Y . Progesterone Intramuscularly or Vaginally Administration May Not Change Live Birth Rate or Neonatal Outcomes in Artificial Frozen-Thawed Embryo Transfer Cycles. Front Endocrinol (Lausanne). 2020; 11:539427. PMC: 7747782. DOI: 10.3389/fendo.2020.539427. View

Coussa A, Hasan H, Barber T . Impact of contraception and IVF hormones on metabolic, endocrine, and inflammatory status. J Assist Reprod Genet. 2020; 37(6):1267-1272. PMC: 7311610. DOI: 10.1007/s10815-020-01756-z. View

Kasum M, Oreskovic S, cehic E, Lila A, Ejubovic E, Soldo D . The role of female obesity on in vitro fertilization outcomes. Gynecol Endocrinol. 2017; 34(3):184-188. DOI: 10.1080/09513590.2017.1391209. View

Edwards R, Fishel S, Cohen J, Fehilly C, Purdy J, Slater J . Factors influencing the success of in vitro fertilization for alleviating human infertility. J In Vitro Fert Embryo Transf. 1984; 1(1):3-23. DOI: 10.1007/BF01129615. View

Maroufizadeh S, Navid B, Omani-Samani R, Amini P . The effects of depression, anxiety and stress symptoms on the clinical pregnancy rate in women undergoing IVF treatment. BMC Res Notes. 2019; 12(1):256. PMC: 6507221. DOI: 10.1186/s13104-019-4294-0. View

Yan J, Wu K, Tang R, Ding L, Chen Z . Effect of maternal age on the outcomes of in vitro fertilization and embryo transfer (IVF-ET). Sci China Life Sci. 2012; 55(8):694-8. DOI: 10.1007/s11427-012-4357-0. View

Miller N, Herzberger E, Pasternak Y, Klement A, Shavit T, Tamir Yaniv R . Does stress affect IVF outcomes? A prospective study of physiological and psychological stress in women undergoing IVF. Reprod Biomed Online. 2019; 39(1):93-101. DOI: 10.1016/j.rbmo.2019.01.012. View

Dokras A, Baredziak L, Blaine J, Syrop C, VanVoorhis B, Sparks A . Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstet Gynecol. 2006; 108(1):61-9. DOI: 10.1097/01.AOG.0000219768.08249.b6. View

10.

Cesta C, Johansson A, Hreinsson J, Rodriguez-Wallberg K, Olofsson J, Holte J . A prospective investigation of perceived stress, infertility-related stress, and cortisol levels in women undergoing in vitro fertilization: influence on embryo quality and clinical pregnancy rate. Acta Obstet Gynecol Scand. 2017; 97(3):258-268. DOI: 10.1111/aogs.13280. View

11.

Law Y, Zhang N, Venetis C, Chambers G, Harris K . The number of oocytes associated with maximum cumulative live birth rates per aspiration depends on female age: a population study of 221 221 treatment cycles. Hum Reprod. 2019; 34(9):1778-1787. DOI: 10.1093/humrep/dez100. View

12.

Nayak S, Ochalski M, Fu B, Wakim K, Chu T, Dong X . Progesterone level at oocyte retrieval predicts in vitro fertilization success in a short-antagonist protocol: a prospective cohort study. Fertil Steril. 2013; 101(3):676-82. DOI: 10.1016/j.fertnstert.2013.11.022. View

13.

Templeton A, Morris J, Parslow W . Factors that affect outcome of in-vitro fertilisation treatment. Lancet. 1996; 348(9039):1402-6. DOI: 10.1016/S0140-6736(96)05291-9. View

14.

Murto T, Bjuresten K, Landgren B, Stavreus-Evers A . Predictive value of hormonal parameters for live birth in women with unexplained infertility and male infertility. Reprod Biol Endocrinol. 2013; 11:61. PMC: 3711921. DOI: 10.1186/1477-7827-11-61. View

15.

Cui Y, Yu H, Meng F, Liu J, Yang F . Prospective study of pregnancy outcome between perceived stress and stress-related hormones. J Obstet Gynaecol Res. 2020; 46(8):1355-1363. DOI: 10.1111/jog.14278. View

16.

Sneed M, Uhler M, Grotjan H, Rapisarda J, Lederer K, Beltsos A . Body mass index: impact on IVF success appears age-related. Hum Reprod. 2008; 23(8):1835-9. DOI: 10.1093/humrep/den188. View

17.

Gnoth C, Maxrath B, Skonieczny T, Friol K, Godehardt E, Tigges J . Final ART success rates: a 10 years survey. Hum Reprod. 2011; 26(8):2239-46. DOI: 10.1093/humrep/der178. View

18.

Rosen M, Shen S, McCulloch C, Rinaudo P, Cedars M, Dobson A . Methylenetetrahydrofolate reductase (MTHFR) is associated with ovarian follicular activity. Fertil Steril. 2007; 88(3):632-8. DOI: 10.1016/j.fertnstert.2006.11.165. View

19.

Danis R, Samplaski M . Sperm Morphology: History, Challenges, and Impact on Natural and Assisted Fertility. Curr Urol Rep. 2019; 20(8):43. DOI: 10.1007/s11934-019-0911-7. View

20.

Laopaiboon M, Lumbiganon P, Intarut N, Mori R, Ganchimeg T, Vogel J . Advanced maternal age and pregnancy outcomes: a multicountry assessment. BJOG. 2014; 121 Suppl 1:49-56. DOI: 10.1111/1471-0528.12659. View