Association of Rs2013162 and Rs2235375 Polymorphisms in Gene with Susceptibility to Non-Syndromic Cleft Lip and Palate

Overview

Journal Avicenna J Med Biotechnol

Specialty Biomedical Engineering

Date 2022 May 31

PMID 35633982

Authors

Masoumeh Soleymani

Asghar Ebadifar

Maryam Khosravi

Emran Esmaeilzadeh

Hamid Reza Khorram Khorshid

Affiliations

Soon will be listed here.

Abstract

Background: Non-syndromic cleft lip occurs by the interaction of environmental and genetic factors. The purpose of the current study was to analyze the association of Single Nucleotide Polymorphisms (SNPs) in and NSCL/P in an Iranian population.

Methods: A group of 105 children with NSCL/P and 185 normal controls were included in the current study. Genotyping of rs2013162 and rs2235375 was performed by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method.

Results: A substantial association of AA and CA genotypes in rs2013162 with the risk of NSCL/P (AA . CC; OR=2.36; 95%CI [1.05-5.29], p=0.004; and CA . CC; OR=0.47; 95%CI [0.28-0.79], p=0.018) was found. However, there were no important associations between A allele and risk of NSCL/P (p=0.980). According to logistic regression analysis results, subjects with GG genotype and G allele in rs2235375 polymorphism had increased risk of NSCL/P.

Conclusion: The polymorphisms are associated with the susceptibility to NSCL/P in Iranian population.

Citing Articles

Correlation between FOXN3-SIN3A complex expression in peripheral blood and non-syndromic cleft lip and palate in Xinjiang.

Duolikun Wufuer , Dilibaier Yimingjiang , Kamilijiang Maimaitiming , Li J, Wulifan Tuoleheng Hua Xi Kou Qiang Yi Xue Za Zhi. 2024; 42(3):313-318.

PMID: 39049650 PMC: 11190867. DOI: 10.7518/hxkq.2024.2023340.

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