Therapeutic Potential of (L.) Harms Leaf Extract for Parkinson's Disease Treatment by Model

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2022 May 31

PMID 35633880

Authors

Hai Trieu Ly

Thi Thu Huong Nguyen

Van Minh Le

Bich Thao Lam

Thi Thu Trinh Mai

Thi Phuong Thao Dang

Affiliations

Soon will be listed here.

Abstract

Parkinson's disease (PD) is characterized by progressive locomotive defects and loss of dopaminergic neurons. leaves are used by Vietnamese as herbal medicines to support the treatment of some diseases related to neurodegeneration such as Parkinson's and Alzheimer's diseases. However, recent scientific data have not provided sufficient evidence for the use of leaves to treat PD or decelerate PD progression. In the present study, the capacity of leaf extract for PD treatment on the dietary supplementation was investigated using dUCH-knockdown model. The results indicated that leaf extract decelerated dopaminergic neuron degeneration induced by dUCH knockdown in not only the larval stage but also the adult stage, which might result in the amelioration in locomotor ability of dUCH-knockdown larvae and flies. Furthermore, antioxidant activities and some key phytochemicals such as saponins, polyphenols, and flavonoids that might contribute to the effects of the leaf extract were identified.

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