B-Dependent Protein Oligomerization Facilitates Layer-by-Layer Growth of Photo/Thermal Responsive Nanofilms

Overview

Journal ACS Macro Lett

Publisher American Chemical Society

Specialty Chemistry

Date 2022 May 28

PMID 35632923

Authors

Jingjing Wei

Wen-Hao Wu

Ri Wang

Zhongguang Yang

Fei Sun

Wen-Bin Zhang

Affiliations

Soon will be listed here.

Abstract

We report the robust growth of an entirely protein-based, photo- and thermoresponsive Layer-by-Layer nanofilm using genetically encoded SpyTag/SpyCatcher chemistry. The process was facilitated by AdoB-induced tetramerization of photoreceptor proteins. Protein cargos can be released from the film in a light-dependent manner, showing its potential for therapeutic protein delivery.

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