Targeting Membrane Trafficking As a Strategy for Cancer Treatment

Overview

Journal Vaccines (Basel)

Date 2022 May 28

PMID 35632546

Authors

Nydia Tejeda-Munoz

Kuo-Ching Mei

Pooja Sheladiya

Julia Monka

Affiliations

Soon will be listed here.

Abstract

Membrane trafficking is emerging as an attractive therapeutic strategy for cancer. Recent reports have found a connection between Wnt signaling, receptor-mediated endocytosis, V-ATPase, lysosomal activity, and macropinocytosis through the canonical Wnt pathway. In macropinocytic cells, a massive internalization of the plasma membrane can lead to the loss of cell-surface cadherins, integrins, and other antigens that mediate cell-cell adhesion, favoring an invasive phenotype. V-ATPase is a key regulator in maintaining proper membrane trafficking, homeostasis, and the earliest developmental decisions in the vertebrate development model system. Here, we review how the interference of membrane trafficking with membrane trafficking inhibitors might be clinically relevant in humans.

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