Vitamin D and Obesity/Adiposity-A Brief Overview of Recent Studies

Overview

Journal Nutrients

Date 2022 May 28

PMID 35631190

Authors

Imene Bennour

Nicole Haroun

Flavie Sicard

Lourdes Mounien

Jean-Francois Landrier

Affiliations

Soon will be listed here.

Abstract

Observational studies classically find an inverse relationship between human plasma 25-hydroxyvitamin D concentration and obesity. However, interventional and genetic studies have failed to provide clear conclusions on the causal effect of vitamin D on obesity/adiposity. Likewise, vitamin D supplementation in obese rodents has mostly failed to improve obesity parameters, whereas several lines of evidence in rodents and prospective studies in humans point to a preventive effect of vitamin D supplementation on the onset of obesity. Recent studies investigating the impact of maternal vitamin D deficiency in women and in rodent models on adipose tissue biology programming in offspring further support a preventive metabolically driven effect of vitamin D sufficiency. The aim of this review is to summarize the state of the knowledge on the relationship between vitamin D and obesity/adiposity in humans and in rodents and the impact of maternal vitamin D deficiency on the metabolic trajectory of the offspring.

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References

Ong L, Booth D, Parnell G . Vitamin D and its Effects on DNA Methylation in Development, Aging, and Disease. Mol Nutr Food Res. 2020; 64(23):e2000437. DOI: 10.1002/mnfr.202000437. View

Valle M, Mitchell P, Pilon G, St-Pierre P, Varin T, Richard D . Cholecalciferol Supplementation Does Not Prevent the Development of Metabolic Syndrome or Enhance the Beneficial Effects of Omega-3 Fatty Acids in Obese Mice. J Nutr. 2021; 151(5):1175-1189. PMC: 8112766. DOI: 10.1093/jn/nxab002. View

Rytter D, Bech B, Halldorsson T, Henriksen T, Grandstrom C, Cohen A . Maternal Vitamin D Status at Week 30 of Gestation and Offspring Cardio-Metabolic Health at 20 Years: A Prospective Cohort Study over Two Decades. PLoS One. 2016; 11(10):e0164758. PMC: 5072548. DOI: 10.1371/journal.pone.0164758. View

Konradsen S, Ag H, Lindberg F, Hexeberg S, Jorde R . Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index. Eur J Nutr. 2008; 47(2):87-91. DOI: 10.1007/s00394-008-0700-4. View

Carlberg C . Nutrigenomics of Vitamin D. Nutrients. 2019; 11(3). PMC: 6470874. DOI: 10.3390/nu11030676. View

Drincic A, Armas L, Van Diest E, Heaney R . Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity. Obesity (Silver Spring). 2012; 20(7):1444-8. DOI: 10.1038/oby.2011.404. View

Nemere I, Safford S, Rohe B, DeSouza M, Farach-Carson M . Identification and characterization of 1,25D3-membrane-associated rapid response, steroid (1,25D3-MARRS) binding protein. J Steroid Biochem Mol Biol. 2004; 89-90(1-5):281-5. DOI: 10.1016/j.jsbmb.2004.03.031. View

Fan Y, Futawaka K, Koyama R, Fukuda Y, Hayashi M, Imamoto M . Vitamin D3/VDR resists diet-induced obesity by modulating UCP3 expression in muscles. J Biomed Sci. 2016; 23(1):56. PMC: 4966724. DOI: 10.1186/s12929-016-0271-2. View

Weber K, Erben R . Differences in triglyceride and cholesterol metabolism and resistance to obesity in male and female vitamin D receptor knockout mice. J Anim Physiol Anim Nutr (Berl). 2012; 97(4):675-83. DOI: 10.1111/j.1439-0396.2012.01308.x. View

10.

Ma K, Wei S, Bi W, Weiler H, Wen S . Effect of Vitamin D Supplementation in Early Life on Children's Growth and Body Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2021; 13(2). PMC: 7914476. DOI: 10.3390/nu13020524. View

11.

Walsh J, Evans A, Bowles S, Naylor K, Jones K, Schoenmakers I . Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health. Am J Clin Nutr. 2016; 103(6):1465-71. DOI: 10.3945/ajcn.115.120139. View

12.

Morales E, Rodriguez A, Valvi D, Iniguez C, Esplugues A, Vioque J . Deficit of vitamin D in pregnancy and growth and overweight in the offspring. Int J Obes (Lond). 2014; 39(1):61-8. DOI: 10.1038/ijo.2014.165. View

13.

Tao T, Kobelski M, Saini V, Demay M . Adipose-specific VDR Deletion Leads to Hepatic Steatosis in Female Mice Fed a Low-Fat Diet. Endocrinology. 2021; 163(2). PMC: 10061053. DOI: 10.1210/endocr/bqab249. View

14.

de Oliveira L, de Azevedo L, Santana J, de Sales L, Pereira-Santos M . Obesity and overweight decreases the effect of vitamin D supplementation in adults: systematic review and meta-analysis of randomized controlled trials. Rev Endocr Metab Disord. 2019; 21(1):67-76. DOI: 10.1007/s11154-019-09527-7. View

15.

Heaney R . Guidelines for optimizing design and analysis of clinical studies of nutrient effects. Nutr Rev. 2013; 72(1):48-54. DOI: 10.1111/nure.12090. View

16.

Pramono A, Jocken J, Goossens G, Blaak E . Vitamin D release across abdominal adipose tissue in lean and obese men: The effect of ß-adrenergic stimulation. Physiol Rep. 2019; 7(24):e14308. PMC: 6928243. DOI: 10.14814/phy2.14308. View

17.

Thway Tint M, Chong M, Aris I, Godfrey K, Quah P, Kapur J . Association between maternal mid-gestation vitamin D status and neonatal abdominal adiposity. Int J Obes (Lond). 2018; 42(7):1296-1305. PMC: 6005346. DOI: 10.1038/s41366-018-0032-2. View

18.

Belenchia A, Johnson S, Ellersieck M, Rosenfeld C, Peterson C . vitamin D deficiency predisposes offspring to long-term adverse adipose tissue effects. J Endocrinol. 2017; 234(3):301-313. PMC: 6647013. DOI: 10.1530/JOE-17-0015. View

19.

Landrier J, Karkeni E, Marcotorchino J, Bonnet L, Tourniaire F . Vitamin D modulates adipose tissue biology: possible consequences for obesity?. Proc Nutr Soc. 2015; 75(1):38-46. DOI: 10.1017/S0029665115004164. View

20.

Nemere I, Hintze K . Novel hormone "receptors". J Cell Biochem. 2007; 103(2):401-7. DOI: 10.1002/jcb.21437. View