Glassy-like Metal Oxide Particles Embedded on Micrometer Thicker Alginate Films As Promising Wound Healing Nanomaterials

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 May 28

PMID 35628396

Authors

Marta Kedzierska

Nisrine Hammi

Joanna Kolodziejczyk-Czepas

Nadia Katir

Maria Bryszewska

Katarzyna Milowska

Abdelkrim El Kadib

Affiliations

Soon will be listed here.

Abstract

Micrometer-thicker, biologically responsive nanocomposite films were prepared starting from alginate-metal alkoxide colloidal solution followed by sol-gel chemistry and solvent removal through evaporation-induced assembly. The disclosed approach is straightforward and highly versatile, allowing the entrapment and growth of a set of glassy-like metal oxide within the network of alginate and their shaping as crake-free transparent and flexible films. Immersing these films in aqueous medium triggers alginate solubilization, and affords water-soluble metal oxides wrapped in a biocompatible carbohydrate framework. Biological activity of the nano-composites films was also studied including their hemolytic activity, methemoglobin, prothrombin, and thrombine time. The effect of the films on fibroblasts and keratinocytes of human skin was also investigated with a special emphasis on the role played by the incorporated metal oxide. This comparative study sheds light on the crucial biological response of the ceramic phase embedded inside of the films, with titanium dioxide being the most promising for wound healing purposes.

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References

Sharma V, Shukla R, Saxena N, Parmar D, Das M, Dhawan A . DNA damaging potential of zinc oxide nanoparticles in human epidermal cells. Toxicol Lett. 2009; 185(3):211-8. DOI: 10.1016/j.toxlet.2009.01.008. View

Strianese M, Basile A, Mazzone A, Morello S, Caterina Turco M, Pellecchia C . Therapeutic potential of a pyridoxal-based vanadium(IV) complex showing selective cytotoxicity for cancer versus healthy cells. J Cell Physiol. 2013; 228(11):2202-9. DOI: 10.1002/jcp.24385. View

Agulhon P, Robitzer M, Habas J, Quignard F . Influence of both cation and alginate nature on the rheological behavior of transition metal alginate gels. Carbohydr Polym. 2014; 112:525-31. DOI: 10.1016/j.carbpol.2014.05.097. View

Hammi N, Wronska N, Katir N, Lisowska K, Marcotte N, Cacciaguerra T . Supramolecular Chemistry-Driven Preparation of Nanostructured, Transformable, and Biologically Active Chitosan-Clustered Single, Binary, and Ternary Metal Oxide Bioplastics. ACS Appl Bio Mater. 2022; 2(1):61-69. DOI: 10.1021/acsabm.8b00306. View

Horie M, Nishio K, Fujita K, Endoh S, Miyauchi A, Saito Y . Protein adsorption of ultrafine metal oxide and its influence on cytotoxicity toward cultured cells. Chem Res Toxicol. 2009; 22(3):543-53. DOI: 10.1021/tx800289z. View

Xie H, Mason M, Wise Sr J . Genotoxicity of metal nanoparticles. Rev Environ Health. 2012; 26(4):251-68. DOI: 10.1515/reveh.2011.033. View

Garcia-Hevia L, Valiente R, Martin-Rodriguez R, Renero-Lecuna C, Gonzalez J, Rodriguez-Fernandez L . Nano-ZnO leads to tubulin macrotube assembly and actin bundling, triggering cytoskeletal catastrophe and cell necrosis. Nanoscale. 2016; 8(21):10963-73. DOI: 10.1039/c6nr00391e. View

Magdolenova Z, Drlickova M, Henjum K, Runden-Pran E, Tulinska J, Bilanicova D . Coating-dependent induction of cytotoxicity and genotoxicity of iron oxide nanoparticles. Nanotoxicology. 2013; 9 Suppl 1:44-56. DOI: 10.3109/17435390.2013.847505. View

Hogan G . Peripheral erythrocyte levels, hemolysis and three vanadium compounds. Experientia. 1990; 46(5):444-6. DOI: 10.1007/BF01954223. View

10.

Ter Horst B, Chouhan G, Moiemen N, Grover L . Advances in keratinocyte delivery in burn wound care. Adv Drug Deliv Rev. 2017; 123:18-32. PMC: 5764224. DOI: 10.1016/j.addr.2017.06.012. View

11.

Perez-Torres I, Guarner-Lans V, Rubio-Ruiz M . Reductive Stress in Inflammation-Associated Diseases and the Pro-Oxidant Effect of Antioxidant Agents. Int J Mol Sci. 2017; 18(10). PMC: 5666780. DOI: 10.3390/ijms18102098. View

12.

Ahamed M, Alhadlaq H, Alam J, Khan M, Ali D, Alarafi S . Iron oxide nanoparticle-induced oxidative stress and genotoxicity in human skin epithelial and lung epithelial cell lines. Curr Pharm Des. 2013; 19(37):6681-90. DOI: 10.2174/1381612811319370011. View

13.

Starkov A, Fiskum G . Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state. J Neurochem. 2003; 86(5):1101-7. DOI: 10.1046/j.1471-4159.2003.01908.x. View

14.

Aguirre M, Juaristi J, Alvarez M, Brandan N . Characteristics of in vivo murine erythropoietic response to sodium orthovanadate. Chem Biol Interact. 2005; 156(1):55-68. DOI: 10.1016/j.cbi.2005.07.003. View

15.

Guari Y, Larionova J, Molvinger K, Folch B, Guerin C . Magnetic water-soluble cyano-bridged metal coordination nano-polymers. Chem Commun (Camb). 2006; (24):2613-5. DOI: 10.1039/b602460b. View

16.

Frindy S, Primo A, Qaiss A, Bouhfid R, Lahcini M, Garcia H . Insightful understanding of the role of clay topology on the stability of biomimetic hybrid chitosan-clay thin films and CO2-dried porous aerogel microspheres. Carbohydr Polym. 2016; 146:353-61. DOI: 10.1016/j.carbpol.2016.03.077. View

17.

Ates B, Koytepe S, Ulu A, Gurses C, Thakur V . Chemistry, Structures, and Advanced Applications of Nanocomposites from Biorenewable Resources. Chem Rev. 2020; 120(17):9304-9362. DOI: 10.1021/acs.chemrev.9b00553. View

18.

McAusland T, van Vloten J, Santry L, Guilleman M, Rghei A, Ferreira E . Combining vanadyl sulfate with Newcastle disease virus potentiates rapid innate immune-mediated regression with curative potential in murine cancer models. Mol Ther Oncolytics. 2021; 20:306-324. PMC: 7868934. DOI: 10.1016/j.omto.2021.01.009. View

19.

Dar A, Shachar M, Leor J, Cohen S . Optimization of cardiac cell seeding and distribution in 3D porous alginate scaffolds. Biotechnol Bioeng. 2002; 80(3):305-12. DOI: 10.1002/bit.10372. View

20.

Versteeg H, Heemskerk J, Levi M, Reitsma P . New fundamentals in hemostasis. Physiol Rev. 2013; 93(1):327-58. DOI: 10.1152/physrev.00016.2011. View