Polymicrobial Biofilm Dynamics of Multidrug-Resistant and Ampicillin-Resistant and Antimicrobial Inhibition by Aqueous Garlic Extract

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2022 May 28

PMID 35625217

Authors

Priya Ashrit

Bindu Sadanandan

Kalidas Shetty

Vijayalakshmi Vaniyamparambath

Affiliations

Soon will be listed here.

Abstract

The polymicrobial biofilm of with exhibits a dynamic interspecies interaction and is refractory to conventional antimicrobials. In this study, a high biofilm-forming multidrug-resistant strain of overcomes inhibition by in a 24 h coculture. However, following treatment with whole Aqueous Garlic Extract (AGE), these individual biofilms of multidrug-resistant M-207 and Ampicillin-resistant ATCC 39936 and their polymicrobial biofilm were prevented, as evidenced by biochemical and structural characterization. This study advances the antimicrobial potential of AGE to inhibit drug-resistant and bacterial-associated polymicrobial biofilms, suggesting the potential for effective combinatorial and synergistic antimicrobial designs with minimal side effects.

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