Diversified Polyketides With Anti-inflammatory Activities From Mangrove Endophytic Fungus KBJYZ-1

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2022 May 27

PMID 35620105

Authors

Guisheng Wang

Zhenhua Yin

Senye Wang

Yilin Yuan

Yan Chen

Wenyi Kang

Affiliations

Soon will be listed here.

Abstract

In total, five new polyketide derivatives: eschscholin B (), dalditone A and B ( and ), (1, 4)-5-methoxy-1,2,3,4-tetrahydronaphthalene-1,4-dio (), and daldilene A (), together with 10 known as analogs (, -) were isolated from the mangrove endophytic fungus KBJYZ-1. Their structures and absolute configurations were established by extensive analysis of NMR and HRESIMS spectra data combined with ECD calculations and the reported literature. Compounds and showed significant cell-based anti-inflammatory activities with IC values of 19.3 and 12.9 μM, respectively. In addition, western blot results suggested that compound effectively inhibits the expression of iNOS and COX-2 in LPS-induced RAW264.7 cells. Further molecular biology work revealed the potential mechanism of exerts anti-inflammatory function by inactivating the MAPK and NF-κB signaling pathways.

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