Psychological Stress, Emotions, and Quality of Life in Men and Women with Congenital Adrenal Hyperplasia

Overview

Journal J Endocrinol Invest

Publisher Springer

Specialty Endocrinology

Date 2022 May 25

PMID 35612812

Authors

L Lasaite

R Navardauskaite

K Semeniene

R Verkauskiene

Affiliations

Soon will be listed here.

Abstract

Aim: The aim was to assess perceived psychological stress, emotional state, and quality of life (QoL) in men and women with congenital adrenal hyperplasia (CAH) in comparison to age- and sex-matched control individuals.

Methods: Participants: 26 patients with CAH (11 men, 15 women, age 14-48 years) and 26 age- and sex-matched control individuals without CAH. Psychological assessment: Perceived Stress Scale, Profile of Mood States2, and WHO Brief Quality of Life Questionnaire.

Results: There were no significant differences in perceived stress, emotional state and QoL scores between men with CAH and control men. Perceived distress (median 14.0 score vs. 10.0 score, p = 0.020), tension-anxiety (median 9.0 score vs. 3.5 score, p = 0.026), depression-dejection (median 12.0 score vs. 5.0 score, p = 0.040), fatigue-inertia (median 13.0 score vs. 7.5 score, p = 0.007) were higher and environmental domain of QoL (median 16.0 score vs. 17.0 score, p = 0.001) was lower in women with CAH than in control women.

Conclusion: Women with congenital adrenal hyperplasia have higher perceived distress, tension-anxiety, depression dejection, fatigue-inertia, and worse environmental aspect of quality of life than age-matched control women, while perceived psychological stress, emotional state and quality of life in men with congenital adrenal hyperplasia do not differ from that of age-matched control men.

Citing Articles

Severe Hyperandrogenism in 46,XX Congenital Adrenal Hyperplasia: Molecular Physiopathology, Late Diagnoses, and Personalized Management.

Cera G, Corsello A, Novizio R, Di Donna V, Locantore P, Paragliola R Int J Mol Sci. 2024; 25(21).

PMID: 39519330 PMC: 11545884. DOI: 10.3390/ijms252111779.

References

Richards S, Aziz N, Bale S, Bick D, Das S, Gastier-Foster J . Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med. 2015; 17(5):405-24. PMC: 4544753. DOI: 10.1038/gim.2015.30. View

Navardauskaite R, Baneviciute K, Songailiene J, Grigalioniene K, cereskevicius D, Sukys M . Impact of Newborn Screening on Clinical Presentation of Congenital Adrenal Hyperplasia. Medicina (Kaunas). 2021; 57(10). PMC: 8540623. DOI: 10.3390/medicina57101035. View

Nordenstrom A, Falhammar H . MANAGEMENT OF ENDOCRINE DISEASE: Diagnosis and management of the patient with non-classic CAH due to 21-hydroxylase deficiency. Eur J Endocrinol. 2018; 180(3):R127-R145. DOI: 10.1530/EJE-18-0712. View

Zainuddin A, Grover S, Shamsuddin K, Mahdy Z . Research on quality of life in female patients with congenital adrenal hyperplasia and issues in developing nations. J Pediatr Adolesc Gynecol. 2013; 26(6):296-304. DOI: 10.1016/j.jpag.2012.08.004. View

Carroll L, Graff C, Wicks M, Thomas A . Living with an invisible illness: a qualitative study exploring the lived experiences of female children with congenital adrenal hyperplasia. Qual Life Res. 2019; 29(3):673-681. DOI: 10.1007/s11136-019-02350-2. View

Strandqvist A, Falhammar H, Lichtenstein P, Hirschberg A, Wedell A, Norrby C . Suboptimal psychosocial outcomes in patients with congenital adrenal hyperplasia: epidemiological studies in a nonbiased national cohort in Sweden. J Clin Endocrinol Metab. 2014; 99(4):1425-32. DOI: 10.1210/jc.2013-3326. View

Han T, Conway G, Willis D, Krone N, Rees D, Stimson R . Relationship between final height and health outcomes in adults with congenital adrenal hyperplasia: United Kingdom congenital adrenal hyperplasia adult study executive (CaHASE). J Clin Endocrinol Metab. 2014; 99(8):E1547-55. DOI: 10.1210/jc.2014-1486. View

Frisen L, Nordenstrom A, Falhammar H, Filipsson H, Holmdahl G, Janson P . Gender role behavior, sexuality, and psychosocial adaptation in women with congenital adrenal hyperplasia due to CYP21A2 deficiency. J Clin Endocrinol Metab. 2009; 94(9):3432-9. DOI: 10.1210/jc.2009-0636. View

Berenbaum S . Beyond Pink and Blue: The Complexity of Early Androgen Effects on Gender Development. Child Dev Perspect. 2018; 12(1):58-64. PMC: 5935256. DOI: 10.1111/cdep.12261. View

10.

Piaget J . The stages of the intellectual development of the child. Bull Menninger Clin. 1962; 26:120-8. View

11.

Kivnick H, Wells C . Untapped richness in Erik H. Erikson's rootstock. Gerontologist. 2013; 54(1):40-50. DOI: 10.1093/geront/gnt123. View

12.

Speiser P, Arlt W, Auchus R, Baskin L, Conway G, Merke D . Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018; 103(11):4043-4088. PMC: 6456929. DOI: 10.1210/jc.2018-01865. View

13.

Garrow J, Webster J . Quetelet's index (W/H2) as a measure of fatness. Int J Obes. 1985; 9(2):147-53. View

14.

Schneiderman N, Ironson G, Siegel S . Stress and health: psychological, behavioral, and biological determinants. Annu Rev Clin Psychol. 2007; 1:607-28. PMC: 2568977. DOI: 10.1146/annurev.clinpsy.1.102803.144141. View

15.

Cohen S, Kamarck T, Mermelstein R . A global measure of perceived stress. J Health Soc Behav. 1983; 24(4):385-96. View

16.

Golden-Kreutz D, Browne M, Frierson G, Andersen B . Assessing stress in cancer patients: a second-order factor analysis model for the Perceived Stress Scale. Assessment. 2004; 11(3):216-23. PMC: 2746492. DOI: 10.1177/1073191104267398. View

17.

Schutzmann K, Brinkmann L, Schacht M, Richter-Appelt H . Psychological distress, self-harming behavior, and suicidal tendencies in adults with disorders of sex development. Arch Sex Behav. 2007; 38(1):16-33. DOI: 10.1007/s10508-007-9241-9. View

18.

Oner O, Aycan Z, Tiryaki T, Soy D, Cetinkaya E, Kibar E . Variables related to behavioral and emotional problems and gender typed behaviors in female patients with congenital adrenal hyperplasia. J Pediatr Endocrinol Metab. 2009; 22(2):143-51. DOI: 10.1515/jpem.2009.22.2.143. View

19.

Hamed S, Attiah F, Abd Elaal R, Fawzy M . Behavioral assessment of females with congenital adrenal hyperplasia. Hormones (Athens). 2020; 20(1):131-141. DOI: 10.1007/s42000-020-00232-8. View

20.

Engberg H, Butwicka A, Nordenstrom A, Linden Hirschberg A, Falhammar H, Lichtenstein P . Congenital adrenal hyperplasia and risk for psychiatric disorders in girls and women born between 1915 and 2010: A total population study. Psychoneuroendocrinology. 2015; 60:195-205. DOI: 10.1016/j.psyneuen.2015.06.017. View