Thermoresponsive Gelatin Nanogels
Overview
Affiliations
We present a novel tunable thermoresponsive gelatin nanogel that shows a volume transition at ∼32 °C. A thermally induced volume reduction of more than 30× is observed due to the helix to random coil transition of gelatin chains confined in the nanogels. The physical process and key factors influencing thermoresponsive properties are investigated using dynamic light scattering (DLS), transmission electron microscopy (TEM), and polarimetry. The thermoresponsive properties of this nanogel can be exploited in the development of new types of stimuli-responsive, biomedically relevant materials based on natural polymers.
Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications.
Ghaeini-Hesaroeiye S, Razmi Bagtash H, Boddohi S, Vasheghani-Farahani E, Jabbari E Gels. 2020; 6(3).
PMID: 32635573 PMC: 7559285. DOI: 10.3390/gels6030020.
Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis.
Das S, Bharadwaj P, Bilal M, Barani M, Rahdar A, Taboada P Polymers (Basel). 2020; 12(6).
PMID: 32580366 PMC: 7362228. DOI: 10.3390/polym12061397.
Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application.
Chatterjee S, Hui P Molecules. 2019; 24(14).
PMID: 31336916 PMC: 6681499. DOI: 10.3390/molecules24142547.
Thermoresponsive and Mechanical Properties of Poly(L-proline) Gels.
Gkikas M, Avery R, Olsen B Biomacromolecules. 2016; 17(2):399-406.
PMID: 26736072 PMC: 4747850. DOI: 10.1021/acs.biomac.5b01168.