Twin Peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 Epidemics in England

Overview

Journal Science

Specialty Science

Date 2022 May 24

PMID 35608440

Authors

Paul Elliott

Oliver Eales

Nicholas Steyn

David Tang

Barbara Bodinier

Haowei Wang

Joshua Elliott

Matthew Whitaker

Christina Atchison

Peter J Diggle

Andrew J Page

Alexander J Trotter

Deborah Ashby

Wendy Barclay

Graham Taylor

Helen Ward

Ara Darzi

Graham S Cooke

Christl A Donnelly

Marc Chadeau-Hyam

Affiliations

Soon will be listed here.

Abstract

Rapid transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has led to record-breaking incidence rates around the world. The Real-time Assessment of Community Transmission-1 (REACT-1) study has tracked SARS-CoV-2 infection in England using reverse transcription polymerase chain reaction (RT-PCR) results from self-administered throat and nose swabs from randomly selected participants aged 5 years and older approximately monthly from May 2020 to March 2022. Weighted prevalence in March 2022 was the highest recorded in REACT-1 at 6.37% ( = 109,181), with the Omicron BA.2 variant largely replacing the BA.1 variant. Prevalence was increasing overall, with the greatest increase in those aged 65 to 74 years and 75 years and older. This was associated with increased hospitalizations and deaths, but at much lower levels than in previous waves against a backdrop of high levels of vaccination.

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