Clinical Outcomes of Single-step Transepithelial Photorefractive Keratectomy and Off-flap Epipolis-laser in Situ Keratomileusis in Moderate to High Myopia: 12-month Follow-up

Overview

Journal BMC Ophthalmol

Publisher Biomed Central

Specialty Ophthalmology

Date 2022 May 23

PMID 35606707

Authors

Yunjie Zhang

Tiankun Li

Zhangliang Li

Mali Dai

Qinmei Wang

Chenchen Xu

Affiliations

Soon will be listed here.

Abstract

Background: To compare the quantitative and qualitative optical outcomes of single-step transepithelial photorefractive keratectomy (TPRK) and off-flap epipolis-laser in situ keratomileusis (Epi-LASIK) in moderate to high myopia.

Methods: In this prospective self-control study, we included patients with moderate to high myopia who were randomized to undergo TPRK in one eye and Epi-LASIK in the other eye. Twelve-month follow-up results for visual acuity, refraction, ocular high-order aberrations, contrast sensitivity, postoperative pain, epithelial healing, and haze grade were assessed.

Results: A total of 64 eyes (32 patients) were enrolled in the study. More eyes completed re-epithelialization in the TPRK group than in the Off-flap Epi-LASIK group 3-4 days postoperatively, while all eyes completed re-epithelialization by 7 days. More eyes achieved a visual acuity (both UDVA and CDVA) of better than 20/20 in the TPRK group than in the Off-flap Epi-LASIK group. The ±0.50 D predictability for correction of the spherical equivalent (SE) was higher in the eyes of the TPRK group (91%) than in those of the off-flap Epi-LASIK group (80%) 12 months after surgery. No significant differences in ocular aberrations, including coma, spherical, and trefoil, were found between the two groups at 12 months. There were also no significant differences in visual acuity, contrast sensitivity, pain, and haze grading between the two groups.

Conclusions: Both TPRK and off-flap Epi-LASIK are safe, effective, and predictable treatments for moderate to high myopia with comparable surgical outcomes.

Trial Registration: This study was retrospectively registered on ClinicalTrial.gov ( NCT05060094 , 17/09/2021).

Citing Articles

Efficacy of single-step transepithelial photorefractive keratectomy in myopia, hyperopia and astigmatism-a systematic review.

Akram S, Moazzum W, Abid K BMC Ophthalmol. 2025; 25(1):93.

PMID: 40001065 PMC: 11863916. DOI: 10.1186/s12886-024-03830-x.

Comparison of Outcomes after Wavefront-optimized and Topography-guided Transepithelial Photorefractive Keratectomy.

Kim S, Na S, Choi S, Choi S Korean J Ophthalmol. 2024; 38(4):275-283.

PMID: 38897594 PMC: 11321827. DOI: 10.3341/kjo.2024.0027.

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