Eight-week Exercise Program Improved the Quality of Life of Alzheimer's Patients Through Functional, Cognitive, and Biochemical Parameters

Overview

Journal Ir J Med Sci

Specialty General Medicine

Date 2022 May 23

PMID 35604540

Authors

Fatih Kar

Yasemin Kavlak

Selda Yildiz

Pinar Yildiz

Ahmet Musmul

Sema Uslu

Affiliations

Soon will be listed here.

Abstract

Objective: In this study, it was aimed to examine the effect of 8-week exercise in Alzheimer's disease (AD) aged 65 and over through functional, cognitive, and biochemical parameters and irisin metabolism.

Methods: Two groups consisting of healthy individuals and diagnosed with Alzheimer's over the age of 65 were followed up with a combined exercise program of 45-60 min, 3 days a week, for 8 weeks. At the end of the exercise period, various cognitive and functional tests were performed on the participants, and blood samples were taken for biochemical parameters and irisin level measurements.

Results: In functional evaluations, while there was no difference in pre-exercise measurements of timed performance and quadriceps femoris muscle strength, there was a difference between groups in all other measurements (p < 0.05). Nutritional status increased significantly after exercise in AD individuals. Although there was an increase in mental score values after exercise, it was not statistically significant. Similar to the elderly with Alzheimer's, the improvements in functional tests in the healthy also led to improvements in activities of daily living and auxiliary activities of daily living. The exercise training did not have an effect on the lipid profile in AD patients, but showed an effect on glycemia and irisin levels (p < 0.05).

Conclusion: Changes in functional, cognitive, and biochemical parameters after the exercise program improved quality of life in Alzheimer's patients.

Citing Articles

Exercise-produced irisin effects on brain-related pathological conditions.

De Sousa R Metab Brain Dis. 2024; 39(8):1679-1687.

PMID: 39145861 DOI: 10.1007/s11011-024-01412-w.

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