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Radiotherapy-drug Combinations in the Treatment of Glioblastoma: a Brief Review

Overview
Journal CNS Oncol
Specialty Oncology
Date 2022 May 23
PMID 35603818
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Abstract

Glioblastoma (GBM) accounts for over 50% of gliomas and carries the worst prognosis of all solid tumors. Owing to the limited local control afforded by surgery alone, efficacious adjuvant treatments such as radiotherapy (RT) and chemotherapy are fundamental in achieving durable disease control. The best clinical outcomes are achieved with tri-modality treatment consisting of surgery, RT and systemic therapy. While RT-chemotherapy combination regimens are well established in oncology, this approach was largely unsuccessful in GBM until the introduction of temozolomide. The success of this combination has stimulated the search for other candidate drugs for concomitant use with RT in GBM. This review seeks to collate the current evidence for these agents and synthesize possible future directions for the field.

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References
1.
Sim H, McDonald K, Lwin Z, Barnes E, Rosenthal M, Foote M . A randomized phase II trial of veliparib, radiotherapy, and temozolomide in patients with unmethylated MGMT glioblastoma: the VERTU study. Neuro Oncol. 2021; 23(10):1736-1749. PMC: 8485443. DOI: 10.1093/neuonc/noab111. View

2.
Omuro A, Vlahovic G, Lim M, Sahebjam S, Baehring J, Cloughesy T . Nivolumab with or without ipilimumab in patients with recurrent glioblastoma: results from exploratory phase I cohorts of CheckMate 143. Neuro Oncol. 2017; 20(5):674-686. PMC: 5892140. DOI: 10.1093/neuonc/nox208. View

3.
Vecchio D, Daga A, Carra E, Marubbi D, Baio G, Neumaier C . Predictability, efficacy and safety of radiosensitization of glioblastoma-initiating cells by the ATM inhibitor KU-60019. Int J Cancer. 2014; 135(2):479-91. DOI: 10.1002/ijc.28680. View

4.
McGranahan T, Therkelsen K, Ahmad S, Nagpal S . Current State of Immunotherapy for Treatment of Glioblastoma. Curr Treat Options Oncol. 2019; 20(3):24. PMC: 6394457. DOI: 10.1007/s11864-019-0619-4. View

5.
Bao S, Wu Q, McLendon R, Hao Y, Shi Q, Hjelmeland A . Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006; 444(7120):756-60. DOI: 10.1038/nature05236. View