Erythrophagocytic Multiple Myeloma in a Dog

Overview

Journal J Vet Diagn Invest

Specialty Veterinary Medicine

Date 2022 May 23

PMID 35603564

Authors

Pierpaolo Romanelli

Camilla Recordati

Paola Rigamonti

Walter Bertazzolo

Affiliations

Soon will be listed here.

Abstract

A 5-y-old spayed female Golden Retriever dog was referred because of severe normocytic normochromic nonregenerative anemia and thrombocytopenia. Serum analysis revealed hyperproteinemia and monoclonal or oligoclonal gammopathy. Fine-needle aspiration of the spleen revealed a highly erythrophagocytic population of neoplastic round cells, morphologically suggestive of plasma cells. After euthanasia, histologic assessment of the spleen and liver revealed an erythrophagocytic round cell tumor. Immunohistochemical analysis of the tumor population was positive for MUM1p and negative for CD3, CD20, and Iba-1, confirming the plasma cell origin of the tumor. Erythrophagocytic multiple myeloma is a very rare neoplastic condition in dogs.

References

Dunbar M, Lyles S . Hemophagocytic syndrome in a cat with multiple myeloma. Vet Clin Pathol. 2013; 42(1):55-60. DOI: 10.1111/vcp.12015. View

Savage D, Zipin D, Bhagat G, Alobeid B . Hemophagocytic, non-secretory multiple myeloma. Leuk Lymphoma. 2004; 45(5):1061-4. DOI: 10.1080/10428190310001623856. View

Tripp C, Bryan J, Wills T . Presumptive increase in protein-bound serum calcium in a dog with multiple myeloma. Vet Clin Pathol. 2009; 38(1):87-90. DOI: 10.1111/j.1939-165X.2008.00102.x. View

Marks S, Moore P, Taylor D, MUNN R . Nonsecretory multiple myeloma in a dog: immunohistologic and ultrastructural observations. J Vet Intern Med. 1995; 9(1):50-4. DOI: 10.1111/j.1939-1676.1995.tb03272.x. View

Stilwell J, Rissi D . Immunohistochemical Labeling of Multiple Myeloma Oncogene 1/Interferon Regulatory Factor 4 (MUM1/IRF-4) in Canine Cutaneous Histiocytoma. Vet Pathol. 2018; 55(4):517-520. DOI: 10.1177/0300985818759770. View

Khandelwal S, Saxena R . Age-dependent increase in green autofluorescence of blood erythrocytes. J Biosci. 2007; 32(6):1139-45. DOI: 10.1007/s12038-007-0115-z. View

Yearley J, Stanton C, Olivry T, Dean G . Phagocytic plasmacytoma in a dog. Vet Clin Pathol. 2007; 36(3):293-6. DOI: 10.1111/j.1939-165x.2007.tb00228.x. View

Ramaiah S, Seguin M, Carwile H, Raskin R . Biclonal gammopathy associated with immunoglobulin A in a dog with multiple myeloma. Vet Clin Pathol. 2002; 31(2):83-9. DOI: 10.1111/j.1939-165x.2002.tb00285.x. View

Djunic I, Elezovic I, Vucic M, Srdic-Rajic T, Konic-Ristic A, Ilic V . Specific binding of paraprotein to platelet receptors as a cause of platelet dysfunction in monoclonal gammopathies. Acta Haematol. 2013; 130(2):101-7. DOI: 10.1159/000345418. View

10.

Appel S, Moens N, Abrams-Ogg A, Woods J, Nykamp S, Bienzle D . Multiple myeloma with central nervous system involvement in a cat. J Am Vet Med Assoc. 2008; 233(5):743-7. DOI: 10.2460/javma.233.5.743. View

11.

Webb J, Chary P, Northrup N, Almy F . Erythrophagocytic multiple myeloma in a cat. Vet Clin Pathol. 2008; 37(3):302-7. DOI: 10.1111/j.1939-165X.2008.00064.x. View

12.

Fritz E, Ludwig H, Scheithauer W, Sinzinger H . Shortened platelet half-life in multiple myeloma. Blood. 1986; 68(2):514-20. View

13.

Barger A, Skowronski M, MacNeill A . Cytologic identification of erythrophagocytic neoplasms in dogs. Vet Clin Pathol. 2012; 41(4):587-9. DOI: 10.1111/j.1939-165x.2012.00472.x. View

14.

Mayer M, Kerr M, Grier C, MacDonald V . Immunoglobulin A multiple myeloma with cutaneous involvement in a dog. Can Vet J. 2008; 49(7):694-702. PMC: 2430402. View

15.

Facchini R, Bertazzolo W, Zuliani D, Bonfanti U, Caldin M, Avallone G . Detection of biclonal gammopathy by capillary zone electrophoresis in a cat and a dog with plasma cell neoplasia. Vet Clin Pathol. 2010; 39(4):440-6. DOI: 10.1111/j.1939-165X.2010.00259.x. View

16.

Ramos-Vara J, Miller M, Valli V . Immunohistochemical detection of multiple myeloma 1/interferon regulatory factor 4 (MUM1/IRF-4) in canine plasmacytoma: comparison with CD79a and CD20. Vet Pathol. 2007; 44(6):875-84. DOI: 10.1354/vp.44-6-875. View

17.

Seelig D, Perry J, Avery A, Avery P . Monoclonal gammopathy without hyperglobulinemia in 2 dogs with IgA secretory neoplasms. Vet Clin Pathol. 2010; 39(4):447-53. DOI: 10.1111/j.1939-165X.2010.00262.x. View

18.

Kucukkaya R, Hacihanefioglu A, Yenerel M, Turgut M, Nalcali M, Keskin H . CD15-expressing phagocytic plasma cells in a patient with multiple myeloma. Blood. 2001; 97(2):581-3. DOI: 10.1182/blood.v97.2.581. View

19.

Meuten D, Moore F, George J . Mitotic Count and the Field of View Area: Time to Standardize. Vet Pathol. 2015; 53(1):7-9. DOI: 10.1177/0300985815593349. View