Liposomes: Structure, Composition, Types, and Clinical Applications

Overview

Journal Heliyon

Specialty Social Sciences

Date 2022 May 23

PMID 35600452

Authors

Hamdi Nsairat

Dima Khater

Usama Sayed

Fadwa Odeh

Abeer Al Bawab

Walhan Alshaer

Affiliations

Soon will be listed here.

Abstract

Liposomes are now considered the most commonly used nanocarriers for various potentially active hydrophobic and hydrophilic molecules due to their high biocompatibility, biodegradability, and low immunogenicity. Liposomes also proved to enhance drug solubility and controlled distribution, as well as their capacity for surface modifications for targeted, prolonged, and sustained release. Based on the composition, liposomes can be considered to have evolved from conventional, long-circulating, targeted, and immune-liposomes to stimuli-responsive and actively targeted liposomes. Many liposomal-based drug delivery systems are currently clinically approved to treat several diseases, such as cancer, fungal and viral infections; more liposomes have reached advanced phases in clinical trials. This review describes liposomes structure, composition, preparation methods, and clinical applications.

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