Pesticide Residue Intake from Fruit and Vegetable Consumption and Risk of Laparoscopically Confirmed Endometriosis

Overview

Journal F S Sci

Specialty Reproductive Medicine

Date 2022 May 22

PMID 35598776

Authors

Nichole A Garzia

Kara Cushing-Haugen

Yu-Han Chiu

Helena Sandoval-Insausti

Jorge E Chavarro

Stacey A Missmer

Holly R Harris

Affiliations

Soon will be listed here.

Abstract

Objective: To examine the association between the intake of fruits and vegetables with high- vs. low-pesticide residue burden and diagnosis of laparoscopically confirmed endometriosis. The etiology of endometriosis is not well understood, but dietary factors may influence the risk. Pesticides may act as endocrine disruptors, and the intake of pesticide-contaminated food is a common exposure pathway.

Design: Prospective cohort study. Hazard ratios and 95% confidence intervals were calculated using multivariable Cox proportional hazard models to evaluate the intake of fruits and vegetables with high- and low-pesticide residues in relation to the diagnosis of laparoscopically confirmed endometriosis.

Setting: Not applicable.

Patient(s): Premenopausal US women (N = 52,053) of the Nurses' Health Study II, aged 34-53 years at study baseline (1999), were followed until 2013. The diet was assessed every 4 years using a validated food frequency questionnaire. A previously developed and validated pesticide residue burden score (PRBS), on the basis of the US Department of Agriculture Pesticide Data Program, was used to assign fruits and vegetables to pesticide residue groups (high/low).

Intervention(s): Not applicable.

Main Outcome Measure(s): Cases of laparoscopically confirmed endometriosis were identified from self-reports to validated questionnaires.

Result(s): During 14 years of follow-up, 956 incidences of laparoscopically confirmed endometriosis were reported. No association was observed between the intake of high- or low-PRBS fruit and vegetable intake and endometriosis (hazard ratio for 5th vs. 1st quintile: high-PRBS intake = 0.94, 95% confidence interval = 0.73-1.23; low-PRBS intake = 1.07, 95% confidence interval = 0.82-1.40). No associations were observed for high- or low-PRBS fruit and vegetable intake by fertility status.

Conclusion(s): No clear associations were observed between high- or low-PRBS fruit and vegetable intake and endometriosis risk among premenopausal women. To our knowledge, this is the first study to evaluate the association between dietary pesticide residue intake and endometriosis. Further research is needed, particularly to evaluate this association among a younger population of women (adolescence or early adulthood) and assess the dietary exposure to specific pesticides or chemical families.

Citing Articles

Diet in Prevention and Treatment of Endometriosis: Current State of Knowledge.

Oszajca K, Adamus A Curr Nutr Rep. 2024; 13(1):49-58.

PMID: 38324218 DOI: 10.1007/s13668-024-00518-y.

References

Chiu Y, Gaskins A, Williams P, Mendiola J, Jorgensen N, Levine H . Intake of Fruits and Vegetables with Low-to-Moderate Pesticide Residues Is Positively Associated with Semen-Quality Parameters among Young Healthy Men. J Nutr. 2016; 146(5):1084-92. PMC: 4841922. DOI: 10.3945/jn.115.226563. View

Zondervan K, Becker C, Koga K, Missmer S, Taylor R, Vigano P . Endometriosis. Nat Rev Dis Primers. 2018; 4(1):9. DOI: 10.1038/s41572-018-0008-5. View

Li A, Chen Z, Lin T, Buck Louis G, Kannan K . Association of urinary metabolites of organophosphate and pyrethroid insecticides, and phenoxy herbicides with endometriosis. Environ Int. 2020; 136:105456. PMC: 7023990. DOI: 10.1016/j.envint.2019.105456. View

Harel Z, Biro F, Kottenhahn R, Rosenthal S . Supplementation with omega-3 polyunsaturated fatty acids in the management of dysmenorrhea in adolescents. Am J Obstet Gynecol. 1996; 174(4):1335-8. DOI: 10.1016/s0002-9378(96)70681-6. View

Upson K, De Roos A, Thompson M, Sathyanarayana S, Scholes D, Barr D . Organochlorine pesticides and risk of endometriosis: findings from a population-based case-control study. Environ Health Perspect. 2013; 121(11-12):1319-24. PMC: 3855515. DOI: 10.1289/ehp.1306648. View

Curl C, Fenske R, Elgethun K . Organophosphorus pesticide exposure of urban and suburban preschool children with organic and conventional diets. Environ Health Perspect. 2003; 111(3):377-82. PMC: 1241395. DOI: 10.1289/ehp.5754. View

Garcia-Penarrubia P, Ruiz-Alcaraz A, Martinez-Esparza M, Marin P, Machado-Linde F . Hypothetical roadmap towards endometriosis: prenatal endocrine-disrupting chemical pollutant exposure, anogenital distance, gut-genital microbiota and subclinical infections. Hum Reprod Update. 2020; 26(2):214-246. DOI: 10.1093/humupd/dmz044. View

Barr D, Olsson A, Wong L, Udunka S, Baker S, Whitehead R . Urinary concentrations of metabolites of pyrethroid insecticides in the general U.S. population: National Health and Nutrition Examination Survey 1999-2002. Environ Health Perspect. 2010; 118(6):742-8. PMC: 2898848. DOI: 10.1289/ehp.0901275. View

Riederer A, Bartell S, Barr D, Ryan P . Diet and nondiet predictors of urinary 3-phenoxybenzoic acid in NHANES 1999-2002. Environ Health Perspect. 2008; 116(8):1015-22. PMC: 2516573. DOI: 10.1289/ehp.11082. View

10.

Yuan C, Spiegelman D, Rimm E, Rosner B, Stampfer M, Barnett J . Relative Validity of Nutrient Intakes Assessed by Questionnaire, 24-Hour Recalls, and Diet Records as Compared With Urinary Recovery and Plasma Concentration Biomarkers: Findings for Women. Am J Epidemiol. 2017; 187(5):1051-1063. PMC: 5928456. DOI: 10.1093/aje/kwx328. View

11.

Shafrir A, Farland L, Shah D, Harris H, Kvaskoff M, Zondervan K . Risk for and consequences of endometriosis: A critical epidemiologic review. Best Pract Res Clin Obstet Gynaecol. 2018; 51:1-15. DOI: 10.1016/j.bpobgyn.2018.06.001. View

12.

Missmer S, Hankinson S, Spiegelman D, Barbieri R, Marshall L, Hunter D . Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors. Am J Epidemiol. 2004; 160(8):784-96. DOI: 10.1093/aje/kwh275. View

13.

Bougie O, Yap M, Sikora L, Flaxman T, Singh S . Influence of race/ethnicity on prevalence and presentation of endometriosis: a systematic review and meta-analysis. BJOG. 2019; 126(9):1104-1115. DOI: 10.1111/1471-0528.15692. View

14.

Willett W, Sampson L, Browne M, Stampfer M, Rosner B, Hennekens C . The use of a self-administered questionnaire to assess diet four years in the past. Am J Epidemiol. 1988; 127(1):188-99. DOI: 10.1093/oxfordjournals.aje.a114780. View

15.

Yuan C, Spiegelman D, Rimm E, Rosner B, Stampfer M, Barnett J . Validity of a Dietary Questionnaire Assessed by Comparison With Multiple Weighed Dietary Records or 24-Hour Recalls. Am J Epidemiol. 2017; 185(7):570-584. PMC: 5859994. DOI: 10.1093/aje/kww104. View

16.

Curl C, Beresford S, Fenske R, Fitzpatrick A, Lu C, Nettleton J . Estimating pesticide exposure from dietary intake and organic food choices: the Multi-Ethnic Study of Atherosclerosis (MESA). Environ Health Perspect. 2015; 123(5):475-83. PMC: 4421765. DOI: 10.1289/ehp.1408197. View

17.

Hyland C, Bradman A, Gerona R, Patton S, Zakharevich I, Gunier R . Organic diet intervention significantly reduces urinary pesticide levels in U.S. children and adults. Environ Res. 2019; 171:568-575. DOI: 10.1016/j.envres.2019.01.024. View

18.

Hu F, Stampfer M, Rimm E, Ascherio A, Rosner B, Spiegelman D . Dietary fat and coronary heart disease: a comparison of approaches for adjusting for total energy intake and modeling repeated dietary measurements. Am J Epidemiol. 1999; 149(6):531-40. DOI: 10.1093/oxfordjournals.aje.a009849. View

19.

Salvini S, Hunter D, Sampson L, Stampfer M, Colditz G, Rosner B . Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption. Int J Epidemiol. 1989; 18(4):858-67. DOI: 10.1093/ije/18.4.858. View

20.

Hu Y, Chiu Y, Hauser R, Chavarro J, Sun Q . Overall and class-specific scores of pesticide residues from fruits and vegetables as a tool to rank intake of pesticide residues in United States: A validation study. Environ Int. 2016; 92-93:294-300. PMC: 4902771. DOI: 10.1016/j.envint.2016.04.028. View