Effect of Isometric Exercise on Blood Pressure in Prehypertensive and Hypertensive Individuals: Protocol for a Systematic Review and Meta-analysis of Randomized Controlled Trials

Overview

Journal Syst Rev

Publisher Biomed Central

Date 2022 May 20

PMID 35596197

Authors

Patricia Caetano de Oliveira

Alexandre M Lehnen

Gustavo Waclawovsky

Affiliations

Soon will be listed here.

Abstract

Background: Systemic arterial hypertension (HTN) is the leading risk factor of cardiovascular disease death. Lifestyle changes are key for the prevention and management of HTN. Regular aerobic exercise training is recommended as part of the management of HTN, and dynamic resistance exercise should be prescribed as an adjuvant to aerobic training. Recent evidence points to the potential benefits of isometric resistance training in reducing blood pressure (BP). Yet, the hypotensive effect of isometric exercise in prehypertensive and hypertensive individuals is not fully understood. Thus, we will examine the effect of isometric exercise in prehypertensive and hypertensive individuals through a systematic review and meta-analysis.

Methods: Our systematic review study will include randomized controlled trials (RCTs) selected from the electronic databases MEDLINE (PubMed), Cochrane, LILACS, EMBASE, Web of Science, and PEDro published in English, Spanish, and Portuguese languages. We will follow the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) and PICOS framework. Our search will involve studies with both male and female participants aged 18 years or more diagnosed with prehypertension or HTN performing one session of isometric exercise (acute effect) or isometric exercise training (chronic effect) compared to a control group (no exercise). We will use the Cochrane Risk of Bias 2 (RoB 2) tool to evaluate the quality of the studies and RStudio software (v1.3.959 for Windows) for statistical analyses.

Discussion: A meta-analysis of a homogeneous sample of prehypertensive and hypertensive individuals involving isometric handgrip exercise alone can further support previous findings and improve our understanding and recommendations for the management of these populations.

Systematic Review Registration: PROSPERO CRD42020213081.

Citing Articles

Effectiveness of Aerobic, Resistance, and Combined Training for Hypertensive Patients: A Randomized Controlled Trial.

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PMID: 38784482 PMC: 11111269. DOI: 10.4314/ejhs.v33i6.17.

Evaluating Intraocular Pressure Alterations during Large Muscle Group Isometric Exercises with Varying Head and Body Positions.

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PMID: 38673387 PMC: 11050476. DOI: 10.3390/ijerph21040476.

Isometric handgrip training, but not a single session, reduces blood pressure in individuals with hypertension: a systematic review and meta-analysis.

Oliveira P, Silva M, Lehnen A, Waclawovsky G J Hum Hypertens. 2022; 37(9):844-853.

PMID: 36379974 DOI: 10.1038/s41371-022-00778-7.

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