Genetics of Atrial Fibrillation-an Update of Recent Findings

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2022 May 19

PMID 35587846

Authors

Aarthi Manoharan

Ravikumar Sambandam

Vishnu Bhat Ballambattu

Affiliations

Soon will be listed here.

Abstract

Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart failure, and premature death. AF has a strong genetic predisposition. This review highlights the recent findings on the genetics of AF from genome-wide association studies (GWAS) and high-throughput sequencing studies. The consensus from GWAS implies that AF is both polygenic and pleiotropic in nature. With the advent of whole-genome sequencing and whole-exome sequencing, rare variants associated with AF pathogenesis have been identified. The recent studies have contributed towards better understanding of AF pathogenesis.

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