High Prevalence of Depressive Symptoms Among People with Pediatric-onset and Adolescent-onset Type 1 Diabetes: A Cross-sectional Analysis of the Diabetes Study from the Center of Tokyo Women's Medical University

Aims/introduction: To investigate the prevalence of depressive symptoms by the age of onset of type 1 diabetes, and its association with the condition of individuals with pediatric- and adolescent-onset type 1 diabetes.

Materials And Methods: This single-center cross-sectional study enrolled Japanese participants with type 1 diabetes. All participants completed a questionnaire about their diabetes-related condition and the Patient Health Questionnaire-9, which was used to evaluate depression. Individuals with a Patient Health Questionnaire-9 score of ≥10 points were defined as having moderate depressive symptoms.

Results: A total of 1,267 participants (mean age 40 years; mean duration of type 1 diabetes 21 years; 68% female; mean glycated hemoglobin 7.8%) were included and classified according to the age of onset of type 1 diabetes to identify the proportion of moderate depressive symptoms in each group: 21% (0-12 years), 18% (13-19 years) and 13% (20-40 years). The prevalence of moderate depressive symptoms was significantly higher among participants with pediatric-onset type 1 diabetes (P < 0.05). Moderate depressive symptoms were associated with increased glycated hemoglobin, neuropathy and hypoglycemia unawareness.

Conclusions: Regular screening for depressive symptoms and hypoglycemia awareness is important. Healthcare professionals should provide appropriate psychosocial care for people with pediatric-onset and adolescent-onset type 1 diabetes from childhood through to adulthood.