Association Between Genetic Polymorphisms of LncRNA and Pulmonary Tuberculosis Risk, Clinical Manifestations in a Chinese Population

Overview

Journal Infect Drug Resist

Publisher Dove Medical Press

Date 2022 May 19

PMID 35586561

Authors

Hong-Miao Li

Li-Jun Wang

Fei Tang

Hai-Feng Pan

Tian-Ping Zhang

Affiliations

Soon will be listed here.

Abstract

Background: Recent studies have shown that abnormal expression of lncRNA NEAT1 is associated with the progression of pulmonary tuberculosis (PTB). The aim of our study was to analyze the relationship between single nucleotide polymorphisms (SNPs) of gene and susceptibility to PTB.

Methods: Four SNPs (rs2239895, rs3741384, rs3825071, rs512715) in gene were genotyped in 479 patients with PTB and 476 controls by improved multiple ligase detection reaction (iMLDR) in a Chinese population.

Results: We found no significant differences in allele and genotype frequencies of gene rs2239895, rs3741384, rs3825071, rs512715 between PTB patients and controls (all > 0.05). There was no statistically significant association between genotype frequency distribution of dominant model, as well as recessive model, and genetic susceptibility to PTB patients (all > 0.05). The TT genotype, T allele frequencies of rs3825071 were significantly increased in sputum smear-positive PTB patients when compared to sputum smear-negative PTB patients ( = 0.010, = 0.003, respectively). Haplotype analysis shown that haplotype frequency was not associated with PTB susceptibility.

Conclusion: gene polymorphisms were not associated with the risk of PTB in Chinese population, and rs3825071 polymorphism might be related to sputum smear-positive in PTB patients.

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