Chinese Classical Music Lowers Blood Pressure and Improves Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats

Overview

Journal Front Pharmacol

Date 2022 May 19

PMID 35586054

Authors

Jingyuan Li

Zhi Yang

Chunmei Zhang

Yang Hu

Hongxuan Li

Meng Zhang

Peili Bu

Shuangxi Wang

Cheng Zhang

Wenjing Li

Affiliations

Soon will be listed here.

Abstract

High blood pressure (BP) plays an important role in the pathogenesis and development of cardiovascular diseases and multi-organ damages. Music has been well known to elicit emotional changes, such as anxiolytic effects. However, whether music therapy lowers BP in spontaneously hypertensive rats (SHR) and the potential mechanism remains unknown. SHRs were, respectively exposed to white noise (WN), Western classical music (WM), Chinese classical music (CCM), rock music (RM), and bisoprolol treatment. WN and WM did not lower systemic BP, but CCM and RM significantly lowered BPs in SHRs. The effects of CCM therapy on lowering systemic BPs is comparable to that of bisoprolol at the dose of low to medium. Combination of CCM treatment with bisoprolol further improved systemic BPs and myocardial hypertrophy in SHRs, compared to CCM treatment or bisoprolol alone. Furthermore, IHC and WB analysis indicated that CCM therapy inhibited the β1/cAMP/PKA and α1/PLC/PKC signalings, but didn't alter the β2/PI3K/Akt signaling. Above all, CCM therapy lowers systemic BPs and alleviates myocardial hypertrophy in hypertensive rats, which may be caused by the inhibitions of β1/cAMP/PKA and α1/PLC/PKC signalings.

References

Sabido M, Hohenberger T, Grassi G . Pharmacological intervention in hypertension using beta-blockers: Real-world evidence for long-term effectiveness. Pharmacol Res. 2018; 130:191-197. DOI: 10.1016/j.phrs.2018.01.010. View

Chen W, Cai H, Zhang C, Ji X, Zhang Y . Is overall blockade superior to selective blockade of adrenergic receptor subtypes in suppressing left ventricular remodeling in spontaneously hypertensive rats?. Hypertens Res. 2010; 33(10):1071-81. DOI: 10.1038/hr.2010.121. View

Li W, Yu H, Yang J, Gao J, Jiang H, Feng M . Anxiolytic effect of music exposure on BDNFMet/Met transgenic mice. Brain Res. 2010; 1347:71-9. DOI: 10.1016/j.brainres.2010.05.080. View

Yildiz M, Oktay A, Stewart M, Milani R, Ventura H, Lavie C . Left ventricular hypertrophy and hypertension. Prog Cardiovasc Dis. 2019; 63(1):10-21. DOI: 10.1016/j.pcad.2019.11.009. View

Lin Z, Dong M, Liu J . Bisoprolol improved endothelial function and myocardium survival of hypertension with stable angina: a randomized double-blinded trial. Eur Rev Med Pharmacol Sci. 2013; 17(6):794-801. View

Yan X, Jin J, Su X, Yin X, Gao J, Wang X . Intestinal Flora Modulates Blood Pressure by Regulating the Synthesis of Intestinal-Derived Corticosterone in High Salt-Induced Hypertension. Circ Res. 2020; 126(7):839-853. DOI: 10.1161/CIRCRESAHA.119.316394. View

Flint A, Conell C, Ren X, Banki N, Chan S, Rao V . Effect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes. N Engl J Med. 2019; 381(3):243-251. DOI: 10.1056/NEJMoa1803180. View

Arendse L, Danser A, Poglitsch M, Touyz R, Burnett Jr J, Llorens-Cortes C . Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure. Pharmacol Rev. 2019; 71(4):539-570. PMC: 6782023. DOI: 10.1124/pr.118.017129. View

Hirooka Y . Sympathetic Activation in Hypertension: Importance of the Central Nervous System. Am J Hypertens. 2020; 33(10):914-926. DOI: 10.1093/ajh/hpaa074. View

10.

Nakamura M, Sadoshima J . Mechanisms of physiological and pathological cardiac hypertrophy. Nat Rev Cardiol. 2018; 15(7):387-407. DOI: 10.1038/s41569-018-0007-y. View

11.

Zanini C, Jardim P, Salgado C, Nunes M, Urzeda F, Carvalho M . Music therapy effects on the quality of life and the blood pressure of hypertensive patients. Arq Bras Cardiol. 2010; 93(5):534-40. DOI: 10.1590/s0066-782x2009001100015. View

12.

Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M . 2018 Practice Guidelines for the management of arterial hypertension of the European Society of Hypertension and the European Society of Cardiology: ESH/ESC Task Force for the Management of Arterial Hypertension. J Hypertens. 2018; 36(12):2284-2309. DOI: 10.1097/HJH.0000000000001961. View

13.

Amaral M, Gomes Neto M, de Queiroz J, Martins-Filho P, Saquetto M, Carvalho V . Effect of music therapy on blood pressure of individuals with hypertension: A systematic review and Meta-analysis. Int J Cardiol. 2016; 214:461-4. DOI: 10.1016/j.ijcard.2016.03.197. View

14.

DiNicolantonio J, Lavie C, Fares H, Menezes A, OKeefe J . Meta-analysis of carvedilol versus beta 1 selective beta-blockers (atenolol, bisoprolol, metoprolol, and nebivolol). Am J Cardiol. 2013; 111(5):765-9. DOI: 10.1016/j.amjcard.2012.11.031. View

15.

Jackson L, Eldahshan W, Fagan S, Ergul A . Within the Brain: The Renin Angiotensin System. Int J Mol Sci. 2018; 19(3). PMC: 5877737. DOI: 10.3390/ijms19030876. View

16.

Lee E, Yeung N, Xu Z, Zhang D, Yu C, Wong S . Effect and Acceptability of Mindfulness-Based Stress Reduction Program on Patients With Elevated Blood Pressure or Hypertension: A Meta-Analysis of Randomized Controlled Trials. Hypertension. 2020; 76(6):1992-2001. DOI: 10.1161/HYPERTENSIONAHA.120.16160. View

17.

Kunikullaya K, Goturu J, Muradi V, Hukkeri P, Kunnavil R, Doreswamy V . Music versus lifestyle on the autonomic nervous system of prehypertensives and hypertensives--a randomized control trial. Complement Ther Med. 2015; 23(5):733-40. DOI: 10.1016/j.ctim.2015.08.003. View

18.

Dhande I, Braun M, Doris P . Emerging Insights Into Chronic Renal Disease Pathogenesis in Hypertension From Human and Animal Genomic Studies. Hypertension. 2021; 78(6):1689-1700. PMC: 8577298. DOI: 10.1161/HYPERTENSIONAHA.121.18112. View

19.

Slivnick J, Lampert B . Hypertension and Heart Failure. Heart Fail Clin. 2019; 15(4):531-541. DOI: 10.1016/j.hfc.2019.06.007. View

20.

SEAR H . Cure by music. West Lond Med J. 2010; 51:9-15. View