MicroRNAs in Peripheral Artery Disease: Potential Biomarkers and Pathophysiological Mechanisms

Overview

Journal Ther Adv Cardiovasc Dis

Publisher Sage Publications

Specialties Cardiology & Vascular Diseases
Pharmacology

Date 2022 May 18

PMID 35583375

Authors

Andrew Ring

Ahmed Ismaeel

Marissa Wechsler

Emma Fletcher

Evlampia Papoutsi

Dimitrios Miserlis

Panagiotis Koutakis

Affiliations

Soon will be listed here.

Abstract

Peripheral artery disease (PAD) is a disease of atherosclerosis in the lower extremities. PAD carries a massive burden worldwide, while diagnosis and treatment options are often lacking. One of the key points of research in recent years is the involvement of microRNAs (miRNAs), which are short 20-25 nucleotide single-stranded RNAs that can act as negative regulators of post-transcriptional gene expression. Many of these miRNAs have been discovered to be misregulated in PAD patients, suggesting a potential utility as biomarkers for PAD diagnosis. miRNAs have also been shown to play an important role in many different pathophysiological aspects involved in the initiation and progression of the disease including angiogenesis, hypoxia, inflammation, as well as other cellular functions like cell proliferation and migration. The research on miRNAs in PAD has the potential to lead to a whole new class of diagnostic tools and treatments.

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