Stress and Inflammatory Bowel Disease: Clear Mind, Happy Colon

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2022 May 18

PMID 35582022

Authors

Joaquim Francisco Maria De Sousa

Smit Paghdar

Taheseen M Khan

Nishant P Patel

Savitri Chandrasekaran

Nicholas Tsouklidis

Affiliations

Soon will be listed here.

Abstract

Inflammatory bowel disease (IBD) is a condition whose prevalence in the general population worldwide is increasing at an exponential pace. Many risk factors affect the incidence, progression, and overall outcome of IBD, one of them being psychological stress. This study examined the relationship between psychological stress and inflammatory bowel disease. A search for relevant studies was conducted using PubMed, Google Scholar, ResearchGate, and SCOPUS. A systematic review was conducted on the relevant articles after critical appraisal. This article mainly focused on studies that evaluated the presence of inflammatory markers observed in individuals who have been diagnosed with IBD and have high levels of psychological stress. It also assessed if lowering an individual's psychological stress could help improve the outcomes of IBD. Psychological stress can have a detrimental effect on individuals diagnosed with IBD. There is a need to conduct studies that can further confirm the association between psychological stressors, mental health conditions, and IBD. We should also encourage medical practitioners to educate patients who have been diagnosed with IBD regarding the benefits of stress reduction.

Citing Articles

Association between depression and anxiety with the risk and flare of inflammatory bowel disease: a systematic review and meta-analysis.

Gong G, Xu C, Zhang Z, Zheng Y Intern Emerg Med. 2024; 20(1):35-46.

PMID: 39361221 DOI: 10.1007/s11739-024-03764-8.

Saffron as a Promising Therapy for Inflammatory Bowel Disease.

Rashid M, Rashid R, Saroya S, Deverapalli M, Brim H, Ashktorab H Nutrients. 2024; 16(14).

PMID: 39064796 PMC: 11280066. DOI: 10.3390/nu16142353.

The Mechanism of "Treating Different Diseases with the Same Treatment" by Qiangji Jianpi Decoction in Ankylosing Spondylitis Combined with Inflammatory Bowel Disease: A Comprehensive Analysis of Multiple Methods.

Zhang X, Zhou L, Qian X Gastroenterol Res Pract. 2024; 2024:9709260.

PMID: 38808131 PMC: 11132832. DOI: 10.1155/2024/9709260.

Psychiatric Comorbidities of Inflammatory Bowel Disease: It Is a Matter of Microglia's Gut Feeling.

Fakhfouri G, Mijailovic N, Rahimian R Cells. 2024; 13(2).

PMID: 38247868 PMC: 10814793. DOI: 10.3390/cells13020177.

The Impact of Psychotrauma and Emotional Stress Vulnerability on Physical and Mental Functioning of Patients with Inflammatory Bowel Disease.

Nass B, Dibbets P, Markus C Int J Environ Res Public Health. 2023; 20(21).

PMID: 37947534 PMC: 10648781. DOI: 10.3390/ijerph20216976.

References

Ananthakrishnan A, Khalili H, Pan A, Higuchi L, de Silva P, Richter J . Association between depressive symptoms and incidence of Crohn's disease and ulcerative colitis: results from the Nurses' Health Study. Clin Gastroenterol Hepatol. 2012; 11(1):57-62. PMC: 3587728. DOI: 10.1016/j.cgh.2012.08.032. View

Bonaz B, Bazin T, Pellissier S . The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. Front Neurosci. 2018; 12:49. PMC: 5808284. DOI: 10.3389/fnins.2018.00049. View

Mulder D, Noble A, Justinich C, Duffin J . A tale of two diseases: the history of inflammatory bowel disease. J Crohns Colitis. 2013; 8(5):341-8. DOI: 10.1016/j.crohns.2013.09.009. View

Sun Y, Li L, Xie R, Wang B, Jiang K, Cao H . Stress Triggers Flare of Inflammatory Bowel Disease in Children and Adults. Front Pediatr. 2019; 7:432. PMC: 6821654. DOI: 10.3389/fped.2019.00432. View

Feuerstein J, Cheifetz A . Crohn Disease: Epidemiology, Diagnosis, and Management. Mayo Clin Proc. 2017; 92(7):1088-1103. DOI: 10.1016/j.mayocp.2017.04.010. View

Zhang Y, Li Y . Inflammatory bowel disease: pathogenesis. World J Gastroenterol. 2014; 20(1):91-9. PMC: 3886036. DOI: 10.3748/wjg.v20.i1.91. View

Tuglu C, Kara S, Caliyurt O, Vardar E, Abay E . Increased serum tumor necrosis factor-alpha levels and treatment response in major depressive disorder. Psychopharmacology (Berl). 2003; 170(4):429-33. DOI: 10.1007/s00213-003-1566-z. View

Bernstein C, Singh S, Graff L, Walker J, Miller N, Cheang M . A prospective population-based study of triggers of symptomatic flares in IBD. Am J Gastroenterol. 2010; 105(9):1994-2002. DOI: 10.1038/ajg.2010.140. View

Persoons P, Vermeire S, Demyttenaere K, Fischler B, Vandenberghe J, Van Oudenhove L . The impact of major depressive disorder on the short- and long-term outcome of Crohn's disease treatment with infliximab. Aliment Pharmacol Ther. 2005; 22(2):101-10. DOI: 10.1111/j.1365-2036.2005.02535.x. View

10.

Bitton A, Dobkin P, Edwardes M, Sewitch M, Meddings J, Rawal S . Predicting relapse in Crohn's disease: a biopsychosocial model. Gut. 2008; 57(10):1386-92. DOI: 10.1136/gut.2007.134817. View

11.

Gerbarg P, Jacob V, Stevens L, Bosworth B, Chabouni F, Defilippis E . The Effect of Breathing, Movement, and Meditation on Psychological and Physical Symptoms and Inflammatory Biomarkers in Inflammatory Bowel Disease: A Randomized Controlled Trial. Inflamm Bowel Dis. 2015; 21(12):2886-96. DOI: 10.1097/MIB.0000000000000568. View

12.

Mawdsley J, Macey M, Feakins R, Langmead L, Rampton D . The effect of acute psychologic stress on systemic and rectal mucosal measures of inflammation in ulcerative colitis. Gastroenterology. 2006; 131(2):410-9. DOI: 10.1053/j.gastro.2006.05.017. View

13.

Loftus Jr E . Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology. 2004; 126(6):1504-17. DOI: 10.1053/j.gastro.2004.01.063. View

14.

Ananthakrishnan A . Epidemiology and risk factors for IBD. Nat Rev Gastroenterol Hepatol. 2015; 12(4):205-17. DOI: 10.1038/nrgastro.2015.34. View

15.

Abraham B, Ahmed T, Ali T . Inflammatory Bowel Disease: Pathophysiology and Current Therapeutic Approaches. Handb Exp Pharmacol. 2017; 239:115-146. DOI: 10.1007/164_2016_122. View

16.

Ordas I, Eckmann L, Talamini M, Baumgart D, Sandborn W . Ulcerative colitis. Lancet. 2012; 380(9853):1606-19. DOI: 10.1016/S0140-6736(12)60150-0. View

17.

Sairenji T, Collins K, Evans D . An Update on Inflammatory Bowel Disease. Prim Care. 2017; 44(4):673-692. DOI: 10.1016/j.pop.2017.07.010. View

18.

Kaplan G, Ng S . Understanding and Preventing the Global Increase of Inflammatory Bowel Disease. Gastroenterology. 2016; 152(2):313-321.e2. DOI: 10.1053/j.gastro.2016.10.020. View

19.

Boye B, Lundin K, Jantschek G, Leganger S, Mokleby K, Tangen T . INSPIRE study: does stress management improve the course of inflammatory bowel disease and disease-specific quality of life in distressed patients with ulcerative colitis or Crohn's disease? A randomized controlled trial. Inflamm Bowel Dis. 2011; 17(9):1863-73. DOI: 10.1002/ibd.21575. View

20.

Kirsner J . Historical origins of current IBD concepts. World J Gastroenterol. 2002; 7(2):175-84. PMC: 4723519. DOI: 10.3748/wjg.v7.i2.175. View