Micro-computed Tomography Assessment of Bone Structure in Aging Mice

Overview

Journal Sci Rep

Specialty Science

Date 2022 May 17

PMID 35581227

Authors

Junbo Shim

Chihiro Iwaya

Catherine G Ambrose

Akiko Suzuki

Junichi Iwata

Affiliations

Soon will be listed here.

Abstract

High-resolution computed tomography (CT) is widely used to assess bone structure under physiological and pathological conditions. Although the analytic protocols and parameters for micro-CT (μCT) analyses in mice are standardized for long bones, vertebrae, and the palms in aging mice, they have not yet been established for craniofacial bones. In this study, we conducted a morphometric assessment of craniofacial bones, in comparison with long bones, in aging mice. Although age-related changes were observed in the microarchitecture of the femur, tibia, vertebra, and basisphenoid bone, and were more pronounced in females than in males, the microarchitecture of both the interparietal bone and body of the mandible, which develop by intramembranous ossification, was less affected by age and sex. By contrast, the condyle of the mandible was more affected by aging in males compared to females. Taken together, our results indicate that mouse craniofacial bones are uniquely affected by age and sex.

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