Recent Advances on Endogenous Gasotransmitters in Inflammatory Dermatological Disorders

Overview

Journal J Adv Res

Specialties General Medicine
Science

Date 2022 May 16

PMID 35572410

Authors

Lian Wang

Xin Xie

Bowen Ke

Wei Huang

Xian Jiang

Gu He

Affiliations

Soon will be listed here.

Abstract

Background: Endogenous gasotransmitters are small gaseous mediators that can be generated endogenously by mammalian organisms. The dysregulation of the gasotransmitter system is associated with numerous disorders ranging from inflammatory diseases to cancers. However, the relevance of these endogenous gasotransmitters, prodrug donors and inhibitors in inflammatory dermatological disorders has not yet been thoroughly reviewed and discussed.

Aim Of Review: This review discusses the recent progress and will provide perspectives on endogenous gasotransmitters in the context of inflammatory dermatological disorders.

Key Scientific Concepts Of Review: Endogenous gasotransmitters nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (HS) are signaling molecules that regulate several physiological and pathological processes. In addition, sulfur dioxide (SO₂), methane (CH), hydrogen gas (H), ammonia (NH), and carbon dioxide (CO) can also be generated endogenously and may take part in physiological and pathological processes. These signaling molecules regulate inflammation, vasodilation, and oxidative stress, offering therapeutic potential and attracting interest in the field of inflammatory dermatological disorders including psoriasis, atopic dermatitis, acne, rosacea, and chronic skin ulcers. The development of effective gas donors and inhibitors is a promising alternative to treat inflammatory dermatological disorders with controllable and precise delivery in the future.

Citing Articles

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