Zinc and Its Role in Vitamin D Function

Overview

Journal Curr Res Physiol

Date 2022 May 16

PMID 35570853

Authors

Ashton Amos

Mohammed S Razzaque

Affiliations

Soon will be listed here.

Abstract

Zinc is an essential mineral with an important relationship with vitamin D. Studies have found that reduced blood zinc levels could predict vitamin D deficiency in adolescent girls, while zinc supplementation increased vitamin D levels in postmenopausal women. In vitro studies using human peritoneal macrophages have found that zinc induced the release of calcitriol (1,25-dihydroxycholecalciferol). Zinc also acts as a cofactor for vitamin D functions, as the transcriptional activity of vitamin D-dependent genes relies on zinc to exert pleiotropic functions, including mineral ion regulation. Vitamin D could also induce zinc transporters to regulate zinc homeostasis. Together, zinc and vitamin D in adequate concentrations help maintain a healthy musculoskeletal system and beyond; however, deficiency in either of these nutrients can result in various disorders affecting almost all body systems. This brief article will focus on the role of zinc in vitamin D functions.

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References

van Driel M, van Leeuwen J . Vitamin D endocrinology of bone mineralization. Mol Cell Endocrinol. 2017; 453:46-51. DOI: 10.1016/j.mce.2017.06.008. View

Wang H, Hu Y, Hao J, Chen Y, Su P, Wang Y . Maternal zinc deficiency during pregnancy elevates the risks of fetal growth restriction: a population-based birth cohort study. Sci Rep. 2015; 5:11262. PMC: 4459238. DOI: 10.1038/srep11262. View

Akimbekov N, Digel I, Sherelkhan D, Lutfor A, Razzaque M . Vitamin D and the Host-Gut Microbiome: A Brief Overview. Acta Histochem Cytochem. 2020; 53(3):33-42. PMC: 7322162. DOI: 10.1267/ahc.20011. View

Kambe T, Tsuji T, Hashimoto A, Itsumura N . The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism. Physiol Rev. 2015; 95(3):749-84. DOI: 10.1152/physrev.00035.2014. View

Lopez V, Kelleher S . Zinc transporter-2 (ZnT2) variants are localized to distinct subcellular compartments and functionally transport zinc. Biochem J. 2009; 422(1):43-52. PMC: 3381892. DOI: 10.1042/BJ20081189. View

Wan L, Zhang Y, Chen M, Liu C, Wu J . Relationship of structure and function of DNA-binding domain in vitamin D receptor. Molecules. 2015; 20(7):12389-99. PMC: 6332450. DOI: 10.3390/molecules200712389. View

Okamura M, Terada T, Katsura T, Inui K . Inhibitory effect of zinc on the absorption of beta-lactam antibiotic ceftibuten via the peptide transporters in rats. Drug Metab Pharmacokinet. 2009; 23(6):464-8. DOI: 10.2133/dmpk.23.464. View

Mechica J, Leite M, Mendonca B, Frazzatto E, Borelli A, Latronico A . A novel nonsense mutation in the first zinc finger of the vitamin D receptor causing hereditary 1,25-dihydroxyvitamin D3-resistant rickets. J Clin Endocrinol Metab. 1997; 82(11):3892-4. DOI: 10.1210/jcem.82.11.4384. View

Kumssa D, Joy E, Ander E, Watts M, Young S, Walker S . Dietary calcium and zinc deficiency risks are decreasing but remain prevalent. Sci Rep. 2015; 5:10974. PMC: 4476434. DOI: 10.1038/srep10974. View

10.

Wastney M, Aamodt R, Rumble W, Henkin R . Kinetic analysis of zinc metabolism and its regulation in normal humans. Am J Physiol. 1986; 251(2 Pt 2):R398-408. DOI: 10.1152/ajpregu.1986.251.2.R398. View

11.

Hossain S, Beydoun M, Beydoun H, Chen X, Zonderman A, Wood R . Vitamin D and breast cancer: A systematic review and meta-analysis of observational studies. Clin Nutr ESPEN. 2019; 30:170-184. PMC: 6570818. DOI: 10.1016/j.clnesp.2018.12.085. View

12.

Razzaque M . The dualistic role of vitamin D in vascular calcifications. Kidney Int. 2010; 79(7):708-14. PMC: 3120050. DOI: 10.1038/ki.2010.432. View

13.

Yu X, Yan C, Yu X, Gao Y, Xu J, Shen X . [Effect of zinc deficiency on the protein expression of vitamin D receptor and calcium binding protein in growth-stage rats duodenal mucosa]. Zhonghua Er Ke Za Zhi. 2006; 44(1):11-4. View

14.

Sowah D, Fan X, Dennett L, Hagtvedt R, Straube S . Vitamin D levels and deficiency with different occupations: a systematic review. BMC Public Health. 2017; 17(1):519. PMC: 5480134. DOI: 10.1186/s12889-017-4436-z. View

15.

Krebs N . Overview of zinc absorption and excretion in the human gastrointestinal tract. J Nutr. 2000; 130(5S Suppl):1374S-7S. DOI: 10.1093/jn/130.5.1374S. View

16.

Gibson R, Raboy V, King J . Implications of phytate in plant-based foods for iron and zinc bioavailability, setting dietary requirements, and formulating programs and policies. Nutr Rev. 2018; 76(11):793-804. DOI: 10.1093/nutrit/nuy028. View

17.

Da Silva T, Hiller C, Gai Z, Kullak-Ublick G . Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016; 163:77-87. DOI: 10.1016/j.jsbmb.2016.04.006. View

18.

Nishito Y, Kambe T . Zinc transporter 1 (ZNT1) expression on the cell surface is elaborately controlled by cellular zinc levels. J Biol Chem. 2019; 294(43):15686-15697. PMC: 6816103. DOI: 10.1074/jbc.RA119.010227. View

19.

Vazquez-Lorente H, Molina-Lopez J, Herrera-Quintana L, Gamarra-Morales Y, Lopez-Gonzalez B, Planells E . Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial. J Trace Elem Med Biol. 2021; 65:126730. DOI: 10.1016/j.jtemb.2021.126730. View

20.

Harika R, Faber M, Samuel F, Kimiywe J, Mulugeta A, Eilander A . Micronutrient Status and Dietary Intake of Iron, Vitamin A, Iodine, Folate and Zinc in Women of Reproductive Age and Pregnant Women in Ethiopia, Kenya, Nigeria and South Africa: A Systematic Review of Data from 2005 to 2015. Nutrients. 2017; 9(10). PMC: 5691713. DOI: 10.3390/nu9101096. View