Extraction Optimization of Mucilage from Seeds of by Response Surface Methodology

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2022 May 14

PMID 35567073

Authors

Syed Nasir Abbas Bukhari

Arshad Ali

Muhammad Ajaz Hussain

Muhammad Tayyab

Nasser F Alotaibi

Mervat A Elsherif

Kashaf Junaid

Hasan Ejaz

Affiliations

Soon will be listed here.

Abstract

seed mucilage (MPM) is composed of glucuronoxylan, which is a swellable, pH-responsive and non-toxic biomaterial. Herein, we aimed to extract MPM from seeds (MP seeds) to ascertain optimization of extraction conditions to get highest yield by response surface methodology, via Box-Behnken design (RSM-BBD). MPM was extracted from MP seeds by a hot water extraction method. The effects of four different parameters on the extraction yield of MPM were evaluated: pH of the extraction medium (1-10), seed/water contact time (1-12 h), the temperature of extraction medium (30-90 °C), and seed/water ratio (1:5-1:35 /). The maximum yield of MPM obtained by Design-Expert software was 10.66% (10.66 g/100 g) at pH 7, seed/water contact time of 6 h, extraction temperature of 50 °C, and seed/water ratio of 1:20 /. The values of ANOVA were found to be less than 0.0001, which indicated that the extraction yield of MPM was significantly affected by all the study parameters. The results revealed that pH and extraction temperature were the most significant factors affecting the yield of MPM. MPM in compressed tablet form showed pH-responsive on-off switching behavior at pH 7.4 and 1.2 in a reversible manner. MPM in compressed tablet form sustained the release of itopride for 16 h following a super case-II transport mechanism and zero-order release kinetics.

Citing Articles

Optimization of ultrasonic-assisted debittering of using response surface methodology, characterization, and evaluation of antioxidant activity.

Chen S, Song S, Tan Y, He S, Ren X, Li Z PeerJ. 2024; 12:e17943.

PMID: 39421421 PMC: 11485051. DOI: 10.7717/peerj.17943.

Polysaccharide-Based Hydrogel from Seeds of : Extraction Optimization by Box-Behnken Design, pH-Responsiveness, and Sustained Drug Release.

Hussain M, Ali A, Alsahli T, Khan N, Sharif A, Haseeb M Gels. 2023; 9(7).

PMID: 37504404 PMC: 10379781. DOI: 10.3390/gels9070525.

Maximizing the extraction yield of plant gum exudate using response surface methodology and artificial neural networking and pharmacological characterization.

Noureen S, Noreen S, Ghumman S, Al-Hussain S, Hameed H, Anwar-Ul-Haq M Sci Rep. 2023; 13(1):10954.

PMID: 37414773 PMC: 10326058. DOI: 10.1038/s41598-023-37847-x.

References

Sui Z, Li L, Liu B, Gu T, Zhao Z, Liu C . Optimum conditions for Radix Rehmanniae polysaccharides by RSM and its antioxidant and immunity activity in UVB mice. Carbohydr Polym. 2012; 92(1):283-8. DOI: 10.1016/j.carbpol.2012.08.087. View

Pooresmaeil M, Namazi H . Facile preparation of pH-sensitive chitosan microspheres for delivery of curcumin; characterization, drug release kinetics and evaluation of anticancer activity. Int J Biol Macromol. 2020; 162:501-511. DOI: 10.1016/j.ijbiomac.2020.06.183. View

Muhammad G, Hussain M, Jantan I, Bukhari S . Mimosa pudica L., a High-Value Medicinal Plant as a Source of Bioactives for Pharmaceuticals. Compr Rev Food Sci Food Saf. 2020; 15(2):303-315. DOI: 10.1111/1541-4337.12184. View

Song H, He M, Gu C, Wei D, Liang Y, Yan J . Extraction Optimization, Purification, Antioxidant Activity, and Preliminary Structural Characterization of Crude Polysaccharide from an Arctic Chlorella sp. Polymers (Basel). 2019; 10(3). PMC: 6414885. DOI: 10.3390/polym10030292. View

Cheng S, He F, Fu L, Zhang Y . Polysaccharide from rubescens: extraction, optimization, characterization and antioxidant activities. RSC Adv. 2022; 11(31):18974-18983. PMC: 9033498. DOI: 10.1039/d1ra01365c. View

Gibaldi M, Feldman S . Establishment of sink conditions in dissolution rate determinations. Theoretical considerations and application to nondisintegrating dosage forms. J Pharm Sci. 1967; 56(10):1238-42. DOI: 10.1002/jps.2600561005. View

Chen Z, Cheng L, He Y, Wei X . Extraction, characterization, utilization as wound dressing and drug delivery of Bletilla striata polysaccharide: A review. Int J Biol Macromol. 2018; 120(Pt B):2076-2085. DOI: 10.1016/j.ijbiomac.2018.09.028. View

Irfan J, Hussain M, Haseeb M, Ali A, Farid-Ul-Haq M, Tabassum T . A pH-sensitive, stimuli-responsive, superabsorbent, smart hydrogel from psyllium () for intelligent drug delivery. RSC Adv. 2022; 11(32):19755-19767. PMC: 9033674. DOI: 10.1039/d1ra02219a. View

Tahmouzi S . Optimization of polysaccharides from Zagros oak leaf using RSM: antioxidant and antimicrobial activities. Carbohydr Polym. 2014; 106:238-46. DOI: 10.1016/j.carbpol.2014.02.028. View

10.

Samavati V . Polysaccharide extraction from Abelmoschus esculentus: optimization by response surface methodology. Carbohydr Polym. 2013; 95(1):588-97. DOI: 10.1016/j.carbpol.2013.02.041. View

11.

Siepmann J, Peppas N . Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev. 2001; 48(2-3):139-57. DOI: 10.1016/s0169-409x(01)00112-0. View

12.

Peppas N . 1. Commentary on an exponential model for the analysis of drug delivery: Original research article: a simple equation for description of solute release: I II. Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres,.... J Control Release. 2014; 190:31-2. View

13.

Nazir S, Wani I, Masoodi F . Extraction optimization of mucilage from Basil ( L.) seeds using response surface methodology. J Adv Res. 2017; 8(3):235-244. PMC: 5315439. DOI: 10.1016/j.jare.2017.01.003. View

14.

You J, Liu C, Feng X, Lu B, Xia L, Zhuang X . In situ synthesis of ZnS nanoparticles onto cellulose/chitosan sponge for adsorption-photocatalytic removal of Congo red. Carbohydr Polym. 2022; 288:119332. DOI: 10.1016/j.carbpol.2022.119332. View

15.

Jouki M, Mortazavi S, Yazdi F, Koocheki A . Optimization of extraction, antioxidant activity and functional properties of quince seed mucilage by RSM. Int J Biol Macromol. 2014; 66:113-24. DOI: 10.1016/j.ijbiomac.2014.02.026. View

16.

Cok M, Viola M, Vecchies F, Sacco P, Furlani F, Marsich E . N-isopropyl chitosan. A pH- and thermo-responsive polysaccharide for gel formation. Carbohydr Polym. 2020; 230:115641. DOI: 10.1016/j.carbpol.2019.115641. View

17.

Liu Z, Dang J, Wang Q, Yu M, Jiang L, Mei L . Optimization of polysaccharides from Lycium ruthenicum fruit using RSM and its anti-oxidant activity. Int J Biol Macromol. 2013; 61:127-34. DOI: 10.1016/j.ijbiomac.2013.06.042. View

18.

Dehghani Soltani M, Meftahizadeh H, Barani M, Rahdar A, Hosseinikhah S, Hatami M . Guar (Cyamopsis tetragonoloba L.) plant gum: From biological applications to advanced nanomedicine. Int J Biol Macromol. 2021; 193(Pt B):1972-1985. DOI: 10.1016/j.ijbiomac.2021.11.028. View

19.

Keshani-Dokht S, Emam-Djomeh Z, Yarmand M, Fathi M . Extraction, chemical composition, rheological behavior, antioxidant activity and functional properties of Cordia myxa mucilage. Int J Biol Macromol. 2018; 118(Pt A):485-493. DOI: 10.1016/j.ijbiomac.2018.06.069. View

20.

Korsmeyer R, Gurny R, Doelker E, Buri P, Peppas N . Mechanisms of potassium chloride release from compressed, hydrophilic, polymeric matrices: effect of entrapped air. J Pharm Sci. 1983; 72(10):1189-91. DOI: 10.1002/jps.2600721021. View