Neuroimaging Techniques As Potential Tools for Assessment of Angiogenesis and Neuroplasticity Processes After Stroke and Their Clinical Implications for Rehabilitation and Stroke Recovery Prognosis

Overview

Journal J Clin Med

Specialty General Medicine

Date 2022 May 14

PMID 35566599

Authors

Lidia Wlodarczyk

Natalia Cichon

Joanna Saluk-Bijak

Michal Bijak

Agata Majos

Elzbieta Miller

Affiliations

Soon will be listed here.

Abstract

Stroke as the most frequent cause of disability is a challenge for the healthcare system as well as an important socio-economic issue. Therefore, there are currently a lot of studies dedicated to stroke recovery. Stroke recovery processes include angiogenesis and neuroplasticity and advances in neuroimaging techniques may provide indirect description of this action and become quantifiable indicators of these processes as well as responses to the therapeutical interventions. This means that neuroimaging and neurophysiological methods can be used as biomarkers-to make a prognosis of the course of stroke recovery and define patients with great potential of improvement after treatment. This approach is most likely to lead to novel rehabilitation strategies based on categorizing individuals for personalized treatment. In this review article, we introduce neuroimaging techniques dedicated to stroke recovery analysis with reference to angiogenesis and neuroplasticity processes. The most beneficial for personalized rehabilitation are multimodal panels of stroke recovery biomarkers, including neuroimaging and neurophysiological, genetic-molecular and clinical scales.

Citing Articles

Mechanisms of Postischemic Stroke Angiogenesis: A Multifaceted Approach.

Hu B, Pei J, Wan C, Liu S, Xu Z, Zou Y J Inflamm Res. 2024; 17:4625-4646.

PMID: 39045531 PMC: 11264385. DOI: 10.2147/JIR.S461427.

Role of microRNA-34a in blood-brain barrier permeability and mitochondrial function in ischemic stroke.

Payne C, Tabassum S, Wu S, Hu H, Gusdon A, Choi H Front Cell Neurosci. 2023; 17:1278334.

PMID: 37927446 PMC: 10621324. DOI: 10.3389/fncel.2023.1278334.

Integrative Approaches in Acute Ischemic Stroke: From Symptom Recognition to Future Innovations.

Saceleanu V, Toader C, Ples H, Covache-Busuioc R, Costin H, Bratu B Biomedicines. 2023; 11(10).

PMID: 37892991 PMC: 10604797. DOI: 10.3390/biomedicines11102617.

New Advances in Diagnostic Radiology for Ischemic Stroke.

Broocks G, Meyer L J Clin Med. 2023; 12(19).

PMID: 37835019 PMC: 10573123. DOI: 10.3390/jcm12196375.

Comparison of virtual reality to physical box and blocks on cortical an neuromuscualar activations in young adults.

Parker S, Ricks B, Zuniga J, Knarr B Sci Rep. 2023; 13(1):16567.

PMID: 37783719 PMC: 10545674. DOI: 10.1038/s41598-023-43073-2.

References

Carmichael S, Tatsukawa K, Katsman D, Tsuyuguchi N, Kornblum H . Evolution of diaschisis in a focal stroke model. Stroke. 2004; 35(3):758-63. DOI: 10.1161/01.STR.0000117235.11156.55. View

Jo J, Lee A, Kim M, Park E, Chang W, Shin Y . Prediction of Motor Recovery Using Quantitative Parameters of Motor Evoked Potential in Patients With Stroke. Ann Rehabil Med. 2016; 40(5):806-815. PMC: 5108707. DOI: 10.5535/arm.2016.40.5.806. View

Wadden K, Peters S, Borich M, Neva J, Hayward K, Mang C . White Matter Biomarkers Associated with Motor Change in Individuals with Stroke: A Continuous Theta Burst Stimulation Study. Neural Plast. 2019; 2019:7092496. PMC: 6378804. DOI: 10.1155/2019/7092496. View

Arai K, Jin G, Navaratna D, Lo E . Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke. FEBS J. 2009; 276(17):4644-52. PMC: 3712842. DOI: 10.1111/j.1742-4658.2009.07176.x. View

Jones T, Kleim J, Greenough W . Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: a quantitative electron microscopic examination. Brain Res. 1996; 733(1):142-8. DOI: 10.1016/0006-8993(96)00792-5. View

Yanev P, Seevinck P, Rudrapatna U, Bouts M, van der Toorn A, Gertz K . Magnetic resonance imaging of local and remote vascular remodelling after experimental stroke. J Cereb Blood Flow Metab. 2016; 37(8):2768-2779. PMC: 5536787. DOI: 10.1177/0271678X16674737. View

Kleindorfer D, Towfighi A, Chaturvedi S, Cockroft K, Gutierrez J, Lombardi-Hill D . 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association. Stroke. 2021; 52(7):e364-e467. DOI: 10.1161/STR.0000000000000375. View

Doughty C, Wang J, Feng W, Hackney D, Pani E, Schlaug G . Detection and Predictive Value of Fractional Anisotropy Changes of the Corticospinal Tract in the Acute Phase of a Stroke. Stroke. 2016; 47(6):1520-6. PMC: 4959886. DOI: 10.1161/STROKEAHA.115.012088. View

Hankey G . Stroke. Lancet. 2016; 389(10069):641-654. DOI: 10.1016/S0140-6736(16)30962-X. View

10.

Winstein C, Stein J, Arena R, Bates B, Cherney L, Cramer S . Guidelines for Adult Stroke Rehabilitation and Recovery: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2016; 47(6):e98-e169. DOI: 10.1161/STR.0000000000000098. View

11.

Mazibuko N, OGorman Tuura R, Sztriha L, ODaly O, Barker G, Williams S . Subacute Changes in -Acetylaspartate (NAA) Following Ischemic Stroke: A Serial MR Spectroscopy Pilot Study. Diagnostics (Basel). 2020; 10(7). PMC: 7399797. DOI: 10.3390/diagnostics10070482. View

12.

Mane R, Chew E, Phua K, Ang K, Vinod A, Guan C . Quantitative EEG as Biomarkers for the Monitoring of Post-Stroke Motor Recovery in BCI and tDCS Rehabilitation. Annu Int Conf IEEE Eng Med Biol Soc. 2018; 2018:3610-3613. DOI: 10.1109/EMBC.2018.8512920. View

13.

Bonkhoff A, Rehme A, Hensel L, Tscherpel C, Volz L, Espinoza F . Dynamic connectivity predicts acute motor impairment and recovery post-stroke. Brain Commun. 2021; 3(4):fcab227. PMC: 8578497. DOI: 10.1093/braincomms/fcab227. View

14.

Rosso C, Samson Y . The ischemic penumbra: the location rather than the volume of recovery determines outcome. Curr Opin Neurol. 2013; 27(1):35-41. DOI: 10.1097/WCO.0000000000000047. View

15.

Merali Z, Huang K, Mikulis D, Silver F, Kassner A . Evolution of blood-brain-barrier permeability after acute ischemic stroke. PLoS One. 2017; 12(2):e0171558. PMC: 5313141. DOI: 10.1371/journal.pone.0171558. View

16.

Rolle C, Baumer F, Jordan J, Berry K, Garcia M, Monusko K . Mapping causal circuit dynamics in stroke using simultaneous electroencephalography and transcranial magnetic stimulation. BMC Neurol. 2021; 21(1):280. PMC: 8283835. DOI: 10.1186/s12883-021-02319-0. View

17.

Grefkes C, Fink G . Reorganization of cerebral networks after stroke: new insights from neuroimaging with connectivity approaches. Brain. 2011; 134(Pt 5):1264-76. PMC: 3097886. DOI: 10.1093/brain/awr033. View

18.

Li S, Carmichael S . Growth-associated gene and protein expression in the region of axonal sprouting in the aged brain after stroke. Neurobiol Dis. 2006; 23(2):362-73. DOI: 10.1016/j.nbd.2006.03.011. View

19.

Alia C, Spalletti C, Lai S, Panarese A, Lamola G, Bertolucci F . Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation. Front Cell Neurosci. 2017; 11:76. PMC: 5352696. DOI: 10.3389/fncel.2017.00076. View

20.

Auriat A, Neva J, Peters S, Ferris J, Boyd L . A Review of Transcranial Magnetic Stimulation and Multimodal Neuroimaging to Characterize Post-Stroke Neuroplasticity. Front Neurol. 2015; 6:226. PMC: 4625082. DOI: 10.3389/fneur.2015.00226. View