Effects of Antioxidants on Pain Perception in Patients with Fibromyalgia-A Systematic Review

Overview

Journal J Clin Med

Specialty General Medicine

Date 2022 May 14

PMID 35566585

Authors

Ana Fernandez-Araque

Zoraida Verde

Clara Torres-Ortega

Maria Sainz-Gil

Veronica Velasco-Gonzalez

Jeronimo Javier Gonzalez-Bernal

Juan Mielgo-Ayuso

Affiliations

Soon will be listed here.

Abstract

In recent years, antioxidant supplements have become popular to counteract the effects of oxidative stress in fibromyalgia and one of its most distressing symptoms, pain. The aim of this systematic review was to summarize the effects of antioxidant supplementation on pain levels perceived by patients diagnosed with fibromyalgia. The words used respected the medical search terms related to our objective including antioxidants, fibromyalgia, pain, and supplementation. Seventeen relevant articles were identified within Medline (PubMed), Scopus, Web of Science (WOS), the Cochrane Database of Systematic Review, and the Cochrane Central Register of Controlled Trials. This review found that antioxidant supplementation is efficient in reducing pain in nine of the studies reviewed. Studies with a duration of supplementation of at least 6 weeks showed a benefit on pain perception in 80% of the patients included in these studies. The benefits shown by vitamins and coenzyme Q10 are remarkable. Further research is needed to identify the effects of other types of antioxidants, such as extra virgin olive oil and turmeric. More homogeneous interventions in terms of antioxidant doses administered and duration would allow the effects on pain to be addressed more comprehensively.

Citing Articles

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