Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 May 14

PMID 35566319

Authors

Arvind Sharma

Kanika Arora

Harapriya Mohapatra

Rakesh K Sindhu

Madalin Bulzan

Simona Cavalu

Gulsheen Paneshar

Hosam O Elansary

Ahmed M El-Sabrout

Eman A Mahmoud

Abdullah Alaklabi

Affiliations

Soon will be listed here.

Abstract

At present, the majority of APIs synthesized today remain challenging tasks for formulation development. Many technologies are being utilized or explored for enhancing solubility, such as chemical modification, novel drug delivery systems (microemulsions, nanoparticles, liposomes, etc.), salt formation, and many more. One promising avenue attaining attention presently is supersaturated drug delivery systems. When exposed to gastrointestinal fluids, drug concentration exceeds equilibrium solubility and a supersaturation state is maintained long enough to be absorbed, enhancing bioavailability. In this review, the latest developments in supersaturated drug delivery systems are addressed in depth.

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