Vitamin D As a Potential Player in Immunologic Control over Multiple Myeloma Cells: Implications for Adjuvant Therapies

Overview

Journal Nutrients

Date 2022 May 14

PMID 35565770

Authors

Piotr Kulig

Karolina Luczkowska

Anna Bielikowicz

Debora Zdrojewska

Bartlomiej Baumert

Boguslaw Machalinski

Affiliations

Soon will be listed here.

Abstract

Multiple myeloma (MM) is a plasma cell malignancy with multifactorial etiology. One of the underlying mechanisms is immune system dysregulation. Immunotherapy is being widely introduced into various MM treatment protocols. Nevertheless, little is known about boosting the immune system with supportive treatment. Although classical actions of vitamin D (VD) are very well established, their non-classical actions related to the modulation of the immune system in MM are still a subject of ongoing research. In this literature review, we intend to summarize research conducted on VD and MM, both in vitro and in vivo, with particular emphasis on immune system modulation, the induction of the differentiation of malignant MM cells, synergic activity with anti-MM drugs, and MM-associated peripheral neuropathy.

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