Current Pathology Model of Pancreatic Cancer

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2022 May 14

PMID 35565450

Authors

Krzysztof Szymonski

Katarzyna Milian-Ciesielska

Ewelina Lipiec

Dariusz Adamek

Affiliations

Soon will be listed here.

Abstract

Pancreatic cancer (PC) is one of the most aggressive and lethal malignant neoplasms, ranking in seventh place in the world in terms of the incidence of death, with overall 5-year survival rates still below 10%. The knowledge about PC pathomechanisms is rapidly expanding. Daily reports reveal new aspects of tumor biology, including its molecular and morphological heterogeneity, explain complicated "cross-talk" that happens between the cancer cells and tumor stroma, or the nature of the PC-associated neural remodeling (PANR). Staying up-to-date is hard and crucial at the same time. In this review, we are focusing on a comprehensive summary of PC aspects that are important in pathologic reporting, impact patients' outcomes, and bring meaningful information for clinicians. Finally, we show promising new trends in diagnostic technologies that might bring a difference in PC early diagnosis.

Citing Articles

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Elevated tissue expression of RANKL and RANK is associated with poorer survival rates in pancreatic cancer patients.

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Combined analytical approach empowers precise spectroscopic interpretation of subcellular components of pancreatic cancer cells.

Szymonski K, Skirlinska-Nosek K, Lipiec E, Sofinska K, Czaja M, Wilkosz N Anal Bioanal Chem. 2023; 415(29-30):7281-7295.

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