Worldwide Burden, Risk Factors, and Temporal Trends of Ovarian Cancer: A Global Study

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2022 May 14

PMID 35565359

Authors

Junjie Huang

Wing Chung Chan

Chun Ho Ngai

Veeleah Lok

Lin Zhang

Don Eliseo Lucero-Prisno 3rd

Wanghong Xu

Zhi-Jie Zheng

Edmar Elcarte

Mellissa Withers

Martin C S Wong

Ncd Global Health Research Group Of Association Of Pacific Rim Universities Apru

Affiliations

Soon will be listed here.

Abstract

This study aimed to investigate the most updated worldwide incidence and mortality, risk factors, and epidemiologic trend of ovarian cancer in different countries, regions, and age groups. The database was used for incidence and mortality rates of ovarian cancer in 2020. Data from and the was accessed for trend analysis. Age-standardized rates (ASRs, per 100,000 persons) were calculated for incidence and mortality. The 10-year annual average percent change (AAPC) was estimated by Joinpoint regression analysis. There was an overall decreasing trend of ovarian cancer, yet its burden has been increasing in lower-income countries and among younger females in some countries. Intensive lifestyle modifications are warranted, especially for the populations at high risk for ovarian cancer, including smoking cessation, alcohol use reduction, physical activity, weight control, and treatment of metabolic diseases.

Citing Articles

Ovarian Cancer in Women with Intellectual Disability: Current Data.

Tretarre B, Satge D Cancers (Basel). 2025; 17(5).

PMID: 40075653 PMC: 11898487. DOI: 10.3390/cancers17050805.

The Role of CA-125 in the Management of Ovarian Cancer: A Systematic Review.

Momenimovahed Z, Mazidimoradi A, Allahqoli L, Salehiniya H Cancer Rep (Hoboken). 2025; 8(3):e70142.

PMID: 40067023 PMC: 11894717. DOI: 10.1002/cnr2.70142.

Assessment of tissue factor pathway inhibitor 2 (TFPI2) as a novel serum marker for malignant tumors of the ovary before and after treatment: A case-control study.

Ogawara Y, Yokota N, Yamada Y, Arakawa N, Sakamaki K, Kobayashi H J Obstet Gynaecol Res. 2025; 51(2):e16241.

PMID: 39971476 PMC: 11839307. DOI: 10.1111/jog.16241.

Benchmarking histopathology foundation models for ovarian cancer bevacizumab treatment response prediction from whole slide images.

Mallya M, Mirabadi A, Farnell D, Farahani H, Bashashati A Discov Oncol. 2025; 16(1):196.

PMID: 39961889 PMC: 11832855. DOI: 10.1007/s12672-025-01973-x.

Oxidative Stress-Related KEAP1 and NRF2 Genes Contributed to the Risk of Epithelial Ovarian Cancer.

Tong X, Zhu X, Wang X, Xu Y, Huang P, Zhou L Biochem Genet. 2025; .

PMID: 39945964 DOI: 10.1007/s10528-025-11044-z.

References

Beral V, Gaitskell K, Hermon C, Moser K, Reeves G, Peto R . Ovarian cancer and smoking: individual participant meta-analysis including 28,114 women with ovarian cancer from 51 epidemiological studies. Lancet Oncol. 2012; 13(9):946-56. PMC: 3431503. DOI: 10.1016/S1470-2045(12)70322-4. View

Torre L, Trabert B, DeSantis C, Miller K, Samimi G, Runowicz C . Ovarian cancer statistics, 2018. CA Cancer J Clin. 2018; 68(4):284-296. PMC: 6621554. DOI: 10.3322/caac.21456. View

Liu Z, Zhang T, Zhao J, Qi S, Du P, Liu D . The association between overweight, obesity and ovarian cancer: a meta-analysis. Jpn J Clin Oncol. 2015; 45(12):1107-15. DOI: 10.1093/jjco/hyv150. View

Arnold M, Sierra M, Laversanne M, Soerjomataram I, Jemal A, Bray F . Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2016; 66(4):683-691. DOI: 10.1136/gutjnl-2015-310912. View

Momenimovahed Z, Tiznobaik A, Taheri S, Salehiniya H . Ovarian cancer in the world: epidemiology and risk factors. Int J Womens Health. 2019; 11:287-299. PMC: 6500433. DOI: 10.2147/IJWH.S197604. View

La Vecchia C . Ovarian cancer: epidemiology and risk factors. Eur J Cancer Prev. 2016; 26(1):55-62. DOI: 10.1097/CEJ.0000000000000217. View

Ng M, Freeman M, Fleming T, Robinson M, Dwyer-Lindgren L, Thomson B . Smoking prevalence and cigarette consumption in 187 countries, 1980-2012. JAMA. 2014; 311(2):183-92. DOI: 10.1001/jama.2013.284692. View

Chang E, Canchola A, Lee V, Clarke C, Purdie D, Reynolds P . Wine and other alcohol consumption and risk of ovarian cancer in the California Teachers Study cohort. Cancer Causes Control. 2006; 18(1):91-103. PMC: 1764867. DOI: 10.1007/s10552-006-0083-x. View

Webb P, Jordan S . Epidemiology of epithelial ovarian cancer. Best Pract Res Clin Obstet Gynaecol. 2016; 41:3-14. DOI: 10.1016/j.bpobgyn.2016.08.006. View

10.

Haier J, Sleeman J, Schafers J . Editorial series: cancer care in low- and middle-income countries. Clin Exp Metastasis. 2019; 36(6):477-480. DOI: 10.1007/s10585-019-10003-4. View

11.

Jayson G, Kohn E, Kitchener H, Ledermann J . Ovarian cancer. Lancet. 2014; 384(9951):1376-88. DOI: 10.1016/S0140-6736(13)62146-7. View

12.

Baldwin L, Huang B, Miller R, Tucker T, Goodrich S, Podzielinski I . Ten-year relative survival for epithelial ovarian cancer. Obstet Gynecol. 2012; 120(3):612-8. DOI: 10.1097/AOG.0b013e318264f794. View

13.

Cottreau C, Ness R, Kriska A . Physical activity and reduced risk of ovarian cancer. Obstet Gynecol. 2000; 96(4):609-14. DOI: 10.1016/s0029-7844(00)00972-8. View

14.

Salehi F, Dunfield L, Phillips K, Krewski D, Vanderhyden B . Risk factors for ovarian cancer: an overview with emphasis on hormonal factors. J Toxicol Environ Health B Crit Rev. 2008; 11(3-4):301-21. DOI: 10.1080/10937400701876095. View

15.

Wei K, Li Y, Zheng R, Zhang S, Liang Z, Cen H . Ovary cancer incidence and mortality in China, 2011. Chin J Cancer Res. 2015; 27(1):38-43. PMC: 4329183. DOI: 10.3978/j.issn.1000-9604.2015.01.05. View

16.

Kim H, Fay M, Feuer E, Midthune D . Permutation tests for joinpoint regression with applications to cancer rates. Stat Med. 2000; 19(3):335-51. DOI: 10.1002/(sici)1097-0258(20000215)19:3<335::aid-sim336>3.0.co;2-z. View

17.

Engholm G, Ferlay J, Christensen N, Bray F, Gjerstorff M, Klint A . NORDCAN--a Nordic tool for cancer information, planning, quality control and research. Acta Oncol. 2010; 49(5):725-36. DOI: 10.3109/02841861003782017. View

18.

Sung H, Ferlay J, Siegel R, Laversanne M, Soerjomataram I, Jemal A . Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021; 71(3):209-249. DOI: 10.3322/caac.21660. View

19.

Rosenberg S, Ruddy K, Tamimi R, Gelber S, Schapira L, Come S . BRCA1 and BRCA2 Mutation Testing in Young Women With Breast Cancer. JAMA Oncol. 2016; 2(6):730-6. PMC: 5002892. DOI: 10.1001/jamaoncol.2015.5941. View

20.

Bray F, Loos A, Tognazzo S, La Vecchia C . Ovarian cancer in Europe: Cross-sectional trends in incidence and mortality in 28 countries, 1953-2000. Int J Cancer. 2004; 113(6):977-90. DOI: 10.1002/ijc.20649. View