Sinonasal Inverted Papilloma and Squamous Cell Carcinoma: Contemporary Management and Patient Outcomes
Overview
Affiliations
Inverted papillomas (IP) are the most common sinonasal tumor with a tendency for recurrence, potential attachment to the orbit and skull base, and risk of malignant degeneration into squamous cell carcinoma (SCC). While the overall rate of recurrence has decreased with the widespread adoption of high-definition endoscopic optics and advanced surgical tools, there remain challenges in managing tumors that are multiply recurrent or involve vital neurovascular structures. Here, we review the state-of-the-art diagnostic tools for IP and IP-degenerated SCC, contemporary surgical management, and propose a surveillance protocol.
EGFR mutations in sinonasal squamous neoplasms: Novel hotspot for exon 20 insertions.
Srivastava K, Kaur K, Verma H, Jain D, Thakar A, Kakkar A Virchows Arch. 2025; .
PMID: 40080145 DOI: 10.1007/s00428-025-04070-0.
Atypical Sinonasal Inverted Papilloma - A Case Report.
Kumar R, Varsha S, Kumar K, Kumar B, Pal S Ann Maxillofac Surg. 2025; 14(2):236-239.
PMID: 39957878 PMC: 11828048. DOI: 10.4103/ams.ams_64_24.
Changes in the Microbiome During Chronic Rhinosinusitis.
de Mezer M, Chalama N, Bratt C, Kiebalo M, Dolata N, Rogalinski J Pathogens. 2025; 14(1).
PMID: 39860975 PMC: 11768233. DOI: 10.3390/pathogens14010014.
Miao S, Cheng Y, Li Y, Chen X, Chen F, Zha D Eur J Med Res. 2024; 29(1):528.
PMID: 39497172 PMC: 11533278. DOI: 10.1186/s40001-024-02099-6.
Buali H, Alrayyes H, Habib H, Ansari S Cureus. 2024; 16(8):e66577.
PMID: 39252714 PMC: 11382738. DOI: 10.7759/cureus.66577.