Immunosuppressive Extracellular Vesicles As a Linking Factor in the Development of Tumor and Endometriotic Lesions in the Gynecologic Tract

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2022 May 14

PMID 35563789

Authors

Karolina Soroczynska

Lukasz Zareba

Magdalena Dlugolecka

Malgorzata Czystowska-Kuzmicz

Affiliations

Soon will be listed here.

Abstract

Both gynecological tumors and endometriosis require for their development a favorable environment, termed in the case of tumors a "pre-metastatic niche" and in case of endometriosis a "pro-endometriotic niche". This is characterized by chronic inflammation and immunosuppression that support the further progression of initial lesions. This microenvironment is established and shaped in the course of a vivid cross-talk between the tumor or endometrial cells with other stromal, endothelial and immune cells. There is emerging evidence that extracellular vesicles (EVs) play a key role in this cellular communication, mediating both in tumors and endometriosis similar immunosuppressive and pro-inflammatory mechanisms. In this review, we discuss the latest findings about EVs as immunosuppressive factors, highlighting the parallels between gynecological tumors and endometriosis. Furthermore, we outline their role as potential diagnostic or prognostic biomarkers as well as their future in therapeutic applications.

Citing Articles

Platelets as key cells in endometriosis patients: Insights from small extracellular vesicles in peritoneal fluid and endometriotic lesions analysis.

Bortot B, Di Florio R, Merighi S, Peacock B, Lees R, Valle F FASEB J. 2024; 38(24):e70267.

PMID: 39698929 PMC: 11656511. DOI: 10.1096/fj.202402499R.

Breaking the silence: The role of extracellular vesicles in unraveling the diagnosis and treatment of endometriosis.

Utkarsh K, Srivastava N, Papayannakos C, Nayyar A, Khan A, Haque S Extracell Vesicles Circ Nucl Acids. 2024; 4(4):599-614.

PMID: 39697806 PMC: 11648450. DOI: 10.20517/evcna.2023.43.

Advances and challenges in the use of liquid biopsy in gynaecological oncology.

Zhang Y, Tian L Heliyon. 2024; 10(20):e39148.

PMID: 39492906 PMC: 11530831. DOI: 10.1016/j.heliyon.2024.e39148.

Extracellular vesicles and their content in the context of polycystic ovarian syndrome and endometriosis: a review.

Duval C, Wyse B, Tsang B, Librach C J Ovarian Res. 2024; 17(1):160.

PMID: 39103867 PMC: 11302210. DOI: 10.1186/s13048-024-01480-7.

PARP-1, EpCAM, and FRα as potential targets for intraoperative detection and delineation of endometriosis: a quantitative tissue expression analysis.

Belmonte B, Lorenzo G, Mangogna A, Bortot B, Bertolazzi G, Sammataro S Reprod Biol Endocrinol. 2024; 22(1):92.

PMID: 39085882 PMC: 11293020. DOI: 10.1186/s12958-024-01264-0.

References

Aalberts M, van Dissel-Emiliani F, van Adrichem N, van Wijnen M, Wauben M, Stout T . Identification of distinct populations of prostasomes that differentially express prostate stem cell antigen, annexin A1, and GLIPR2 in humans. Biol Reprod. 2011; 86(3):82. DOI: 10.1095/biolreprod.111.095760. View

Poole E, Lin W, Kvaskoff M, De Vivo I, Terry K, Missmer S . Endometriosis and risk of ovarian and endometrial cancers in a large prospective cohort of U.S. nurses. Cancer Causes Control. 2017; 28(5):437-445. PMC: 5410866. DOI: 10.1007/s10552-017-0856-4. View

Szajnik M, Czystowska M, Szczepanski M, Mandapathil M, Whiteside T . Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg). PLoS One. 2010; 5(7):e11469. PMC: 2908536. DOI: 10.1371/journal.pone.0011469. View

Li Y, Yang Y, Xiong A, Wu X, Xie J, Han S . Comparative Gene Expression Analysis of Lymphocytes Treated with Exosomes Derived from Ovarian Cancer and Ovarian Cysts. Front Immunol. 2017; 8:607. PMC: 5451634. DOI: 10.3389/fimmu.2017.00607. View

Giusti I, Di Francesco M, DAscenzo S, Palmerini M, Macchiarelli G, Carta G . Ovarian cancer-derived extracellular vesicles affect normal human fibroblast behavior. Cancer Biol Ther. 2018; 19(8):722-734. PMC: 6067870. DOI: 10.1080/15384047.2018.1451286. View

Zhang Y, Liu Y, Liu H, Tang W . Exosomes: biogenesis, biologic function and clinical potential. Cell Biosci. 2019; 9:19. PMC: 6377728. DOI: 10.1186/s13578-019-0282-2. View

McDonald M, Bender D . Endometrial Cancer: Obesity, Genetics, and Targeted Agents. Obstet Gynecol Clin North Am. 2019; 46(1):89-105. DOI: 10.1016/j.ogc.2018.09.006. View

Gobbo J, Marcion G, Cordonnier M, Dias A, Pernet N, Hammann A . Restoring Anticancer Immune Response by Targeting Tumor-Derived Exosomes With a HSP70 Peptide Aptamer. J Natl Cancer Inst. 2015; 108(3. DOI: 10.1093/jnci/djv330. View

Khalaj K, Miller J, Lingegowda H, Fazleabas A, Young S, Lessey B . Extracellular vesicles from endometriosis patients are characterized by a unique miRNA-lncRNA signature. JCI Insight. 2019; 4(18). PMC: 6795291. DOI: 10.1172/jci.insight.128846. View

10.

Kajiyama H, Suzuki S, Yoshihara M, Tamauchi S, Yoshikawa N, Niimi K . Endometriosis and cancer. Free Radic Biol Med. 2018; 133:186-192. DOI: 10.1016/j.freeradbiomed.2018.12.015. View

11.

Meng Y, Kang S, Fishman D . Lysophosphatidic acid stimulates fas ligand microvesicle release from ovarian cancer cells. Cancer Immunol Immunother. 2005; 54(8):807-14. PMC: 11034202. DOI: 10.1007/s00262-004-0642-5. View

12.

Kim J, Herlyn D, Wong K, Park D, Schorge J, Lu K . Identification of epithelial cell adhesion molecule autoantibody in patients with ovarian cancer. Clin Cancer Res. 2003; 9(13):4782-91. View

13.

Asare-Werehene M, Communal L, Carmona E, Han Y, Song Y, Burger D . Plasma Gelsolin Inhibits CD8 T-cell Function and Regulates Glutathione Production to Confer Chemoresistance in Ovarian Cancer. Cancer Res. 2020; 80(18):3959-3971. DOI: 10.1158/0008-5472.CAN-20-0788. View

14.

Harp D, Driss A, Mehrabi S, Chowdhury I, Xu W, Liu D . Exosomes derived from endometriotic stromal cells have enhanced angiogenic effects in vitro. Cell Tissue Res. 2016; 365(1):187-96. PMC: 4917586. DOI: 10.1007/s00441-016-2358-1. View

15.

Brooks N, Pouniotis D . Immunomodulation in endometrial cancer. Int J Gynecol Cancer. 2009; 19(4):734-40. DOI: 10.1111/IGC.0b013e3181a12f7f. View

16.

Liang Y, Wu J, Wang W, Xie H, Yao S . Pro-endometriotic niche in endometriosis. Reprod Biomed Online. 2019; 38(4):549-559. DOI: 10.1016/j.rbmo.2018.12.025. View

17.

Zondervan K, Becker C, Koga K, Missmer S, Taylor R, Vigano P . Endometriosis. Nat Rev Dis Primers. 2018; 4(1):9. DOI: 10.1038/s41572-018-0008-5. View

18.

Dutsch-Wicherek M, Szubert S, Dziobek K, Wisniewski M, Lukaszewska E, Wicherek L . Analysis of the treg cell population in the peripheral blood of ovarian cancer patients in relation to the long-term outcomes. Ginekol Pol. 2019; 90(4):179-184. DOI: 10.5603/GP.2019.0032. View

19.

Bacci M, Capobianco A, Monno A, Cottone L, Di Puppo F, Camisa B . Macrophages are alternatively activated in patients with endometriosis and required for growth and vascularization of lesions in a mouse model of disease. Am J Pathol. 2009; 175(2):547-56. PMC: 2716955. DOI: 10.2353/ajpath.2009.081011. View

20.

Ohlsson Teague E, Van der Hoek K, Van der Hoek M, Perry N, Wagaarachchi P, Robertson S . MicroRNA-regulated pathways associated with endometriosis. Mol Endocrinol. 2008; 23(2):265-75. PMC: 5419313. DOI: 10.1210/me.2008-0387. View