A2B5 Expression in Central Nervous System and Gliomas

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 May 14

PMID 35563061

Authors

Dominique Figarella-Branger

Carole Colin

Nathalie Baeza-Kallee

Aurelie Tchoghandjian

Affiliations

Soon will be listed here.

Abstract

A2B5 IgM recognizes c-series gangliosides with three sialic acids. The aim of this review was to focus on A2B5 expression in the central nervous system and gliomas. In brain development, A2B5+ cells are recorded in areas containing multipotent neural stem cells (NSC). In adults, A2B5+ cells persist in neurogenic areas and in white matter where it identifies oligodendrocyte precursor cells (OPCs) but also cells with NSC properties. Although the expression of A2B5 has been widely studied in culture, where it characterizes bipotential glial progenitor cells, its expression in vivo is less characterized mainly because of technical issues. A new interest was given to the NSCs and OPCs since the discovery of cancer stem cells (CSC) in gliomas. Among other cell surface molecules, A2B5 has been identified as an accurate marker to identify glioma CSCs. We and others have shown that all types of gliomas express A2B5, and that only A2B5+ cells, and not A2B5- cells, can generate a tumor after orthotopic implantation in immunocompromised animals. Moreover, A2B5 epitope expression is positively correlated with stemness and tumor growth. This review highlights that A2B5 is an attractive target to tackle glioma CSCs, and a better characterization of its expression in the developing and adult CNS will benefit to a better understanding of gliomagenesis.

Citing Articles

Build muscles and protect myelin.

Bose A, Pahan K NeuroImmune Pharm Ther. 2025; 3(3-4):175-182.

PMID: 39741558 PMC: 11683878. DOI: 10.1515/nipt-2024-0015.

Mesenchymal Properties of Glioma Cell Lines.

Kholodenko I, Lupatov A, Kim Y, Saryglar R, Kholodenko R, Yarygin K Bull Exp Biol Med. 2024; 178(1):122-129.

PMID: 39585593 DOI: 10.1007/s10517-024-06294-7.

Combined inhibition of EZH2 and CDK4/6 perturbs endoplasmic reticulum-mitochondrial homeostasis and increases antitumor activity against glioblastoma.

Freitag T, Kaps P, Ramtke J, Bertels S, Zunke E, Schneider B NPJ Precis Oncol. 2024; 8(1):156.

PMID: 39054369 PMC: 11272933. DOI: 10.1038/s41698-024-00653-3.

S100B actions on glial and neuronal cells in the developing brain: an overview.

Hernandez-Ortega K, Canul-Euan A, Solis-Paredes J, Borboa-Olivares H, Reyes-Munoz E, Estrada-Gutierrez G Front Neurosci. 2024; 18:1425525.

PMID: 39027325 PMC: 11256909. DOI: 10.3389/fnins.2024.1425525.

GD3 ganglioside is a promising therapeutic target for glioma patients.

Hein V, Baeza-Kallee N, Bertucci A, Colin C, Tchoghandjian A, Figarella-Branger D Neurooncol Adv. 2024; 6(1):vdae038.

PMID: 38590763 PMC: 11000324. DOI: 10.1093/noajnl/vdae038.

References

Auvergne R, Sim F, Wang S, Chandler-Militello D, Burch J, Al Fanek Y . Transcriptional differences between normal and glioma-derived glial progenitor cells identify a core set of dysregulated genes. Cell Rep. 2013; 3(6):2127-41. PMC: 5293199. DOI: 10.1016/j.celrep.2013.04.035. View

Ffrench-Constant C, Raff M . Proliferating bipotential glial progenitor cells in adult rat optic nerve. Nature. 1986; 319(6053):499-502. DOI: 10.1038/319499a0. View

Stallcup W . The NG2 antigen, a putative lineage marker: immunofluorescent localization in primary cultures of rat brain. Dev Biol. 1981; 83(1):154-65. DOI: 10.1016/s0012-1606(81)80018-8. View

Pouly S, Becher B, Blain M, Antel J . Expression of a homologue of rat NG2 on human microglia. Glia. 1999; 27(3):259-68. DOI: 10.1002/(sici)1098-1136(199909)27:3<259::aid-glia7>3.0.co;2-8. View

Zhou H, He Y, Wang Z, Wang Q, Hu C, Wang X . Identifying the functions of two biomarkers in human oligodendrocyte progenitor cell development. J Transl Med. 2021; 19(1):188. PMC: 8088696. DOI: 10.1186/s12967-021-02857-8. View

Pietras A, Katz A, Ekstrom E, Wee B, Halliday J, Pitter K . Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth. Cell Stem Cell. 2014; 14(3):357-69. PMC: 3999042. DOI: 10.1016/j.stem.2014.01.005. View

Dirkse A, Golebiewska A, Buder T, Nazarov P, Muller A, Poovathingal S . Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment. Nat Commun. 2019; 10(1):1787. PMC: 6467886. DOI: 10.1038/s41467-019-09853-z. View

Zecevic N, Chen Y, Filipovic R . Contributions of cortical subventricular zone to the development of the human cerebral cortex. J Comp Neurol. 2005; 491(2):109-22. PMC: 2628573. DOI: 10.1002/cne.20714. View

Mountney A, Zahner M, Lorenzini I, Oudega M, Schramm L, Schnaar R . Sialidase enhances recovery from spinal cord contusion injury. Proc Natl Acad Sci U S A. 2010; 107(25):11561-6. PMC: 2895144. DOI: 10.1073/pnas.1006683107. View

10.

Fenderson B, Andrews P, Nudelman E, Clausen H, Hakomori S . Glycolipid core structure switching from globo- to lacto- and ganglio-series during retinoic acid-induced differentiation of TERA-2-derived human embryonal carcinoma cells. Dev Biol. 1987; 122(1):21-34. DOI: 10.1016/0012-1606(87)90328-9. View

11.

Espinosa de Los Monteros A, Zhang M, de Vellis J . O2A progenitor cells transplanted into the neonatal rat brain develop into oligodendrocytes but not astrocytes. Proc Natl Acad Sci U S A. 1993; 90(1):50-4. PMC: 45597. DOI: 10.1073/pnas.90.1.50. View

12.

Ishii A, Ohta M, Watanabe Y, Matsuda K, Ishiyama K, Sakoe K . Expression cloning and functional characterization of human cDNA for ganglioside GM3 synthase. J Biol Chem. 1998; 273(48):31652-5. DOI: 10.1074/jbc.273.48.31652. View

13.

Obernier K, Alvarez-Buylla A . Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain. Development. 2019; 146(4). PMC: 6398449. DOI: 10.1242/dev.156059. View

14.

Roy N, Wang S, Benraiss A, Fraser R, Gravel M, Braun P . Identification, isolation, and promoter-defined separation of mitotic oligodendrocyte progenitor cells from the adult human subcortical white matter. J Neurosci. 1999; 19(22):9986-95. PMC: 6782951. View

15.

Nishiyama A, Lin X, Giese N, Heldin C, Stallcup W . Interaction between NG2 proteoglycan and PDGF alpha-receptor on O2A progenitor cells is required for optimal response to PDGF. J Neurosci Res. 1996; 43(3):315-30. DOI: 10.1002/(SICI)1097-4547(19960201)43:3<315::AID-JNR6>3.0.CO;2-M. View

16.

Erhart F, Blauensteiner B, Zirkovits G, Printz D, Soukup K, Klingenbrunner S . Gliomasphere marker combinatorics: multidimensional flow cytometry detects CD44+/CD133+/ITGA6+/CD36+ signature. J Cell Mol Med. 2018; 23(1):281-292. PMC: 6307809. DOI: 10.1111/jcmm.13927. View

17.

Scherer S, Braun P, Grinspan J, Collarini E, Wang D, Kamholz J . Differential regulation of the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene during oligodendrocyte development. Neuron. 1994; 12(6):1363-75. DOI: 10.1016/0896-6273(94)90451-0. View

18.

Ehtesham M, Mapara K, Stevenson C, Thompson R . CXCR4 mediates the proliferation of glioblastoma progenitor cells. Cancer Lett. 2008; 274(2):305-12. PMC: 2628453. DOI: 10.1016/j.canlet.2008.09.034. View

19.

Verhaak R, Hoadley K, Purdom E, Wang V, Qi Y, Wilkerson M . Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010; 17(1):98-110. PMC: 2818769. DOI: 10.1016/j.ccr.2009.12.020. View

20.

Baracskay K, Kidd G, Miller R, Trapp B . NG2-positive cells generate A2B5-positive oligodendrocyte precursor cells. Glia. 2007; 55(10):1001-10. DOI: 10.1002/glia.20519. View